[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618287":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":26,"responsibleParty":41,"collaborators":26,"id":45,"slug":26,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":26,"enrollmentInfo":54,"targetDuration":26,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":26,"overallStatus":65,"whyStopped":26,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":26},{"fullName":5,"class":6},"Air Force Military Medical University, China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Colloid","EXPERIMENTAL","5 ml\u002Fkg of hydroxyethyl starch 130\u002F0.4 electrolyte injection.",[13],"Drug: Hydroxyethyl starch 130\u002F0.4",{"label":15,"type":16,"description":17,"interventionNames":18},"Crystalloid","ACTIVE_COMPARATOR","5 ml\u002Fkg of sodium lactate Ringer's solution is administered before anesthesia induction.",[19],"Drug: Lactate Ringer's Solution",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Hydroxyethyl starch 130\u002F0.4","5 ml\u002Fkg of hydroxyethyl starch 130\u002F0.4 electrolyte injection is administered by infusion pump over 15 minutes before anesthesia induction.",[9],null,{"type":22,"name":28,"description":17,"armGroupLabels":29,"otherNames":26},"Lactate Ringer's Solution",[15],[31],{"name":32,"affiliation":33,"role":34},"Hailong Dong","Air Force Medical University","STUDY_CHAIR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Zhihong Lu","CONTACT","86-13891975018","deerlu23@163.com",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Zhihong LU","associate professor","100618287",false,"NCT07329660","Crystalloid vs Colloid for Hemodynamics During Anesthesia Induction in TAVR Patients","The Impact of Different Preload Strategies on Hemodynamics During Anesthesia Induction in TAVR Patients","CHAIN-T","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Patients scheduled to undergo elective TAVR under general anesthesia;\n\nExclusion Criteria:\n\n* Allergy to hydroxyethyl starch, its components, and\u002For sodium lactate Ringer's solution, or a history of colloidal allergy;\n* Severe cardiac dysfunction (ejection fraction\\[EF\\] \\\u003C 35%);\n* Severe renal dysfunction (creatinine \\> 132 μg\u002FL and\u002For requiring renal replacement therapy);\n* Morbid obesity (body mass index\\[BMI\\] \\> 37.5 kg\u002Fm² or \\> 32.5 kg\u002Fm² with metabolic diseases);\n* Severe hepatic dysfunction ;\n* Severe electrolyte disturbances ;\n* Patients with preoperative intracranial hypertension requiring dehydration therapy;\n* Expected postoperative hospital stay \\\u003C 24 hours;\n* Patients scheduled for multiple surgeries during this hospitalization.","ALL","18 Years",{"count":55,"type":56},116,"ESTIMATED","INTERVENTIONAL",[59],"NA","The purpose of this study is to evaluate whether the administration of 5 ml\u002Fkg of colloid solution prior to anesthesia induction, compared with 5 ml\u002Fkg of lactated Ringer's solution, can reduce hemodynamic fluctuations during the induction period (defined as the first 15 minutes after induction) in patients undergoing Transcatheter Aortic Valve Replacement (TAVR).",[62,63,64],"Transcatheter Aortic Valve Replacement","Hemodynamic Stability","Anesthesia Induction","NOT_YET_RECRUITING","2026-02-25",{"date":68,"type":69},"2026-02-27","ACTUAL",{"date":71,"type":56},"2026-02-16",{"date":73,"type":56},"2026-12-31",{"name":5,"class":6}]