[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590057":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":25,"responsibleParty":38,"collaborators":25,"id":41,"slug":25,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":25,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":25,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":62,"whyStopped":25,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":25},{"fullName":5,"class":6},"South Valley University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tadalafil Group","EXPERIMENTAL","Diabetic male patients with erectile dysfunction will receive oral tadalafil 5 mg once daily for 3 months to assess changes in serum Endothelin-1 and E-selectin levels.",[13],"Drug: Methyl Cellulose Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Group","PLACEBO_COMPARATOR","Healthy male participants matched by age will receive oral placebo tablets (methyl cellulose) once daily for 3 months. Blood samples will be collected pre- and post-intervention for biomarker assessment.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Methyl Cellulose Placebo","Oral administration of inert methyl cellulose placebo tablets once daily for 3 months. Used as a comparator in healthy control participants to evaluate changes in Endothelin-1 and E-selectin serum levels.",[15,9],null,[27],{"name":28,"affiliation":29,"role":30},"Abdelmawgoud, M.Sc","Faculty of Medicine, South Valley University","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Ahmed K Abdelmawgoud, M.Sc","CONTACT","01066152814","+20","amed66177@gmail.com",{"type":30,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Ahmed Khalid Abdelmawgoud","Resident Doctor","100590057",false,"NCT06962462","Daily Tadalafil in Diabetic ED Patients","Effect of Daily Tadalafil Therapy on Endothelin-1 and E-Selectin in Diabetic Patients With Erectile Dysfunction","Inclusion Criteria:\n\nMale patients aged between 30 and 60 yearsز Diagnosed with diabetes mellitus Suffering from erectile dysfunction No history of hypertension or other systemic diseases\n\nExclusion Criteria:\n\nHistory of pelvic trauma or major pelvic surgery Pacientes con hipogonadismo o hiperprolactinemia Chronic liver disease or cardiovascular disorders Chronic use of central nervous system drugs, anti-androgenic drugs, or Tramadol Smokers Non-vasculogenic erectile dysfunction Known allergy to tadalafil",true,"MALE","30 Years","60 Years",{"count":52,"type":53},60,"ESTIMATED","INTERVENTIONAL",[56],"NA","This study evaluates the effect of 5 mg daily tadalafil therapy on serum levels of Endothelin-1 and E-selectin in diabetic male patients with erectile dysfunction. Outcomes will be compared pre- and post-treatment versus healthy controls.",[59],"Erectile Dysfunction Associated With Type 2 Diabetes Mellitus",[61],"Tadalafil, Endothelin-1, E-selectin, Diabetic complications, Sexual dysfunction, ELISA","NOT_YET_RECRUITING","2025-05-07",{"date":65,"type":66},"2025-05-08","ACTUAL",{"date":68,"type":53},"2025-05-05",{"date":70,"type":53},"2025-08-30",{"name":5,"class":6}]