[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599452":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":43,"collaborators":20,"id":47,"slug":20,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":20,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":29,"whyStopped":20,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Texas Tech University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Hydration-Dehydration-Rehydration (HDR) Protocol Arm","EXPERIMENTAL","Participants in this arm complete the HDR Protocol over 12 days and attend five lab visits.",[13],"Behavioral: Hydration-Dehydration-Rehydration Protocol (HDR)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Hydration-Dehydration-Rehydration Protocol (HDR)","The HDR Protocol is a 12-day, sequential fluid manipulation intervention designed to assess the physiological effects of controlled changes in hydration status. The protocol consists of three consecutive 4-day phases:\n\nHydration Phase (Days 1-4): Participants follow a standardized fluid intake protocol designed to promote and maintain a euhydrated state. Hydration status is monitored using objective measures such as urine specific gravity and body mass.\n\nDehydration Phase (Days 5-8): Participants adhere to a fluid-restriction regimen to induce a hypohydrated state. The level of dehydration is verified through the same hydration status measures to ensure consistent and safe hypohydration.\n\nRehydration Phase (Days 9-12): Participants resume the standardized fluid intake protocol used during the Hydration Phase to restore euhydration. Rehydration effectiveness is confirmed through repeated hydration assessments.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Hui Ying Luk, Ph.D.","CONTACT","806-834-0827","huiying.luk@ttu.edu",[28],{"facility":5,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Lubbock","Texas","79409","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-101.85517,33.57786,{"lat":39,"lon":38},[42],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Hui Ying Luk","Assistant Professor","100599452",false,"NCT07084675","Dehydration, Rehydration, and Impact on Physiology","Impact of Mild Dehydration and Subsequent Rehydration on Cellular Stress and Physiological Performance","DRIP","Inclusion Criteria:\n\n* Apparently Healthy\n* BMI \\\u003C 30 kg\u002Fm2\n* Body weight is at least 110 lbs\n\nExclusion Criteria:\n\n* Currently pregnant\n* Have Type 1 Diabetes or Type 2 Diabetes\n* Have chronic kidney disease or a history of kidney stones\n* Have hypertension\n* Take medications that can cause fluid retention, such as corticosteroids, chronic use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Hormonal Therapies (e.g., estrogen, androgens or anabolic steroids), Antihypertensives, Psychiatric Medications (e.g., Lithium), Vasodilators\n* Take medications that reduce fluid retention: diuretics, and RAAS Inhibitors (e.g., ACE inhibitors and ARBs)",true,"ALL","45 Years","65 Years",{"count":59,"type":60},15,"ESTIMATED","INTERVENTIONAL",[63],"NA","Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65.\n\nAim 1: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on H2O2, upstream inflammatory signal (NFkB), mitochondrial fragmentation, and autophagy in circulating PBMCs.\n\nAim 2: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on fasting glucose, sleep performance, and strength performance.\n\nParticipant will:\n\ncomplete a 4-day hydration protocol, followed by a 4-day dehydration protocol, and then a 4-day rehydration protocol.\n\nattend five laboratory visits for testing: Day 1: Informed consent and familiarization Day 2: Pre-hydration testing (before the 4-day hydration protocol) Day 3: Pre-dehydration testing (before the dehyration protocol) Day 4: Post-dehydration testing (after the dehydration protocol) Day 5: Post-rehydration testing (after the rehydration protocol)",[66],"Aging",[68,69],"rehydration","hypohydration","2025-09-11",{"date":72,"type":73},"2025-09-17","ACTUAL",{"date":75,"type":73},"2025-07-15",{"date":77,"type":60},"2026-12",{"name":5,"class":6},1]