Health TrialsbyHealthPanel

Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain

ConditionNeuropathy;Peripheral
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorSwiss Paraplegic Research, Nottwil

About this trial

The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Group (1) patients with neuropathic pain

Group (2) patients with chronic postoperative pain

Disqualifiers

severe psychiatric disorder requiring hospitalisation in the past

any neurological disease other than the pain diagnosis

Trial population

patients with neuropathic pain or with chronic postoperative pain

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • neurophysiology

    Diagnostic test

    electrophysiologic measurements of peripheral nerves

Treatment groups

75 Participants
are divided into 2 treatment groups
Group A: chronic pain1 intervention
Group B: neuropathic pain1 intervention

Trial outcomes

Primary outcomes

1

change in pain intensity

numeric rating scale (NRS), rating from 0-10, 0=no pain, 10=maximum pain imaginable

Time frame
at baseline and during electric nerve stimulation

Secondary outcomes

1

heat pain threshold

Ramped stimuli (+1 degree Celsius / sec) that are terminated when the subject presses a button.

Time frame
baseline
2

cold pain threshold

Ramped stimuli (-1 degree Celsius / sec) that are terminated when the subject presses a button.

Time frame
baseline
3

mechanical detection threshold

Fine plastic hairs with different bending forces are applied to the skin to determine the mechanical detection threshold.

Time frame
baseline
4

mechanical pain threshold

Differently weighted pinprick stimuli are applied at a rate of 2sec on and 2sec off in an ascending order until the first percept of sharpness is reached.

Time frame
baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Swiss Paraplegic Research, Nottwil

Lead sponsor

Source ClinicalTrials.gov
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