Determining Which Regions of the Brain Are Active During Flight Simulation at Separate Timepoints During Training

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-54
SponsorThe Geneva Foundation

About this trial

The overall objective is to identify the cognitive circuits associated with military aviator performance by analyzing what anatomic regions of the brain are functionally "active" (neuronal circuit) while being performing virtual flight simulations, the Precision Instrument Control Task (PICT). The flight simulation test will be conducted at two separate timepoints while the subject is receiving a Functional Magnetic Resonance Imaging (fMRI) scan to evaluate which anatomic and functional brain function is associated with precise performance. By scanning at multiple time points we aim to quantify changes in functional and anatomic connectivity that occur throughout the course of training.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Active Duty Military Pilots (Instructor Pilot Trainees or Remote Piloted Aircraft Trainees)

Age 18-54 years

Biological male or female

Disqualifiers

Age < 18 years

Age > 60 years

Non-active-duty members

History of recurrent migraine headaches requiring chronic suppressive medication or prescription drug intervention more frequently than once per year.

Trial design

Design model

Single group

Treatments tested in this trial

  • fMRI with virtual reality flight simulator

    Diagnostic test

    During this scan, the subject will be wearing the stereogenic goggles called the Visual System HD (NordicNeuroLab) mounted in the scanner via a headcoil that can be adjusted to the subject's comfort using the control arm and completely cover the eyes to prevent light exposure and to clearly visualize eye movement during the flight simulation. The subject will be using a visual response system with customized grips to simulate a stick and throttle in a jet cockpit while visualizing the flight simulation (PICT) in the goggles.

Treatment groups

150 Participants
are divided into 1 treatment group
Group A: Functional (fMRI) and anatomic MRI imaging a two timepoints during pilot virtual reality simulationExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Flight simulation scores of responses (reaction times and latency)

Assess the flight simulation scores of responses (reaction times and latency) to the anatomical and functional regions of the brain that react when performing corrective flight actions. This will occur by analyzing anatomical MRI and fMRI imaging data and correlate with simulator performance.

Time frame
From enrollment to the end of treatment at 30 months

Secondary outcomes

Other outcomes

Sponsors and contacts

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The Geneva Foundation

Lead sponsor

59th Medical Wing

Collaborator

Uniformed Services University of the Health Sciences

Collaborator