Health TrialsbyHealthPanel

Dextromethorphan for Treatment of Postoperative Pain

ConditionPost-operative Pain
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorNathanael Heckmann

About this trial

A Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Perioperative Dextromethorphan compared to Placebo for the Treatment of Postoperative Pain

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients Age ≥18 planning to undergo total knee arthroplasty

ASA classes I - III

Disqualifiers

BMI ≥ 35

History opioid abuse

History of intractable vomiting after previous surgery

Trial design

Design model

Parallel

Treatments tested in this trial

  • Dextromethorphan Hydrobromide

    Drug

    PO

  • Placebo

    Drug

    PO

Treatment groups

160 Participants
are divided into 2 treatment groups
Group A: DextromethorphanExperimental treatment 1 intervention
Group B: PlaceboPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Post-op opioid use

Time frame
24 hours

Secondary outcomes

1

Subjective pain

numeric rating scale (NRS) or visual analog scale (VAS)

Time frame
preoperatively and 6, 12, 24, and 48 hours postoperatively
2

Postoperative opioid consumption

Time frame
at 48 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Nathanael Heckmann

Lead sponsor

University of Southern California

Sponsor institution

Source ClinicalTrials.gov
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