[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498094":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":21,"responsibleParty":35,"collaborators":7,"id":37,"slug":7,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":7,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":7,"enrollmentInfo":45,"targetDuration":7,"studyType":48,"phases":7,"briefSummary":49,"conditions":50,"keywords":7,"overallStatus":23,"whyStopped":7,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":62},{"fullName":5,"class":6},"Queen Mary University of London","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"William Drake, Prof","PRINCIPAL_INVESTIGATOR",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Yun Ni Lee","CONTACT","+442078827275","y.n.lee@qmul.ac.uk",{"name":19,"role":15,"phone":16,"phoneExt":7,"email":20},"Tumi Kaminskas","research.governance@qmul.ac.uk",[22],{"facility":5,"status":23,"city":24,"state":7,"zip":7,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"RECRUITING","London","United Kingdom","UK",{"type":28,"coordinates":29},"Point",[30,31],-0.12574,51.50853,{"lat":31,"lon":30},[34],{"name":14,"role":15,"phone":7,"phoneExt":7,"email":17},{"type":36,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100498094",false,"NCT05765786","Diagnosing Variable Primary Aldosteronism.","Do we Miss a Common Subset of Primary Aldosteronism in Which There is Cyclical or Exaggerated Diurnal Variation in Secretion?","Inclusion Criteria:\n\n* People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \\\u003C0.5 nmol\u002Fh\u002FL or renin mass \\\u003C5 ng\u002FL), plasma sodium \\> 140mmol\u002FL or plasma potassium \\\u003C 4mmol\u002FL.\n* Patients who have been diagnosed with PA and had previous aldosterone samples \\\u003C277 pmol\u002FL, a level which would normally not qualify for confirmatory testing.\n* Patients with aldosterone results done at different times that indicate variability in production.\n* Willing to consent and participate in the study.\n\nExclusion Criteria:\n\n* Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.\n* People on end of life treatment.","ALL","18 Years",{"count":46,"type":47},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.",[51,52],"Primary Aldosteronism","High Blood Pressure","2026-06-12",{"date":55,"type":56},"2026-06-15","ACTUAL",{"date":58,"type":56},"2023-02-24",{"date":60,"type":47},"2027-07-24",{"name":5,"class":6},1]