[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573090":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":32,"locations":42,"responsibleParty":79,"collaborators":31,"id":83,"slug":31,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":84,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":31,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":106,"overallStatus":113,"whyStopped":31,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Direct Warming method","EXPERIMENTAL","The blastocyst designated for thawing will be placed in a pre-warmed, direct warming medium for one minute. Afterward, the embryo is transferred into an embryo culture medium within a time-lapse system, where it remains until the patient is ready for the embryo transfer procedure. This direct warming method significantly reduces the total procedure time to approximately 3 minutes, making it about ten times faster than the conventional multi-step thawing method.",[13],"Other: Direct Warming Method",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional multi-step thawing method","PLACEBO_COMPARATOR","In the conventional multi-step thawing method, vitrified blastocysts are sequentially thawed using a series of pre-warmed thawing, dilution, and washing solutions. The blastocyst is first placed in a thawing solution for 1-3 minutes, followed by immersion in a dilution solution for 4-6 minutes to reduce cryoprotectant concentration. Finally, the blastocyst is transferred to a washing solution for 5-10 minutes for rehydration. The entire process takes approximately 30 minutes, after which the embryo is placed into an embryo culture medium in a time-lapse system until it is ready for embryo transfer.",[19],"Other: Conventional Multi-step Thawing Method",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Direct Warming Method","This intervention involves thawing vitrified blastocysts using a simplified, one-step direct warming method. The blastocyst is placed in a pre-warmed embryo culture medium for approximately one minute, then transferred directly into the embryo culture medium within a time-lapse system until ready for uterine transfer. The total thawing process takes approximately three minutes, reducing the duration and complexity of the procedure compared to conventional methods.",[9],[26],"One-step thawing",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Conventional Multi-step Thawing Method","This intervention involves thawing vitrified blastocysts using a standard, multi-step process. The procedure includes sequential exposure of the blastocyst to different thawing solutions containing varying concentrations of cryoprotectants, followed by its transfer into an embryo culture medium in a time-lapse system. The overall process takes approximately 10-30 minutes.",[15],null,[33,38],{"name":34,"role":35,"phone":36,"phoneExt":31,"email":37},"Yiu Leung D Chan, DPhil","CONTACT","(852) 3505 3199","drdcyl16@cuhk.edu.hk",{"name":39,"role":35,"phone":40,"phoneExt":31,"email":41},"Waner Wu, MPhil","(852) 3505 1764","wanerwu@link.cuhk.edu.hk",[43,51,64],{"facility":44,"status":31,"city":45,"state":46,"zip":31,"country":47,"countryCode":48,"cosmosGeoPoint":31,"geoPoint":31,"contacts":49},"The Chinese University of Hong Kong","Shatin, New Territories","Hong Kong SAR","Hong Kong","HK",[50],{"name":31,"role":35,"phone":40,"phoneExt":31,"email":31},{"facility":52,"status":31,"city":53,"state":46,"zip":31,"country":47,"countryCode":48,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"The CUHK Medical centre","Shatin,NT",{"type":55,"coordinates":56},"Point",[57,58],114.18333,22.38333,{"lat":58,"lon":57},[61],{"name":62,"role":35,"phone":63,"phoneExt":31,"email":37},"Yiu Leung, David Chan","+852 3946 6888",{"facility":65,"status":31,"city":66,"state":66,"zip":31,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"The Homerton Hospital","London","United Kingdom","UK",{"type":55,"coordinates":70},[71,72],-0.12574,51.50853,{"lat":72,"lon":71},[75],{"name":76,"role":35,"phone":77,"phoneExt":31,"email":78},"Priya Bhide","020 8510 5555","p.bhide@qmul.ac.uk",{"type":80,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Yiu Leung David Chan","Assistant Professor","100573090",false,"NCT06741748","Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology","A Pragmatic, Multi-centre, Double-blinded, Two-arm Randomized Controlled Trial on a Direct Warming Frozen Embryo Transfer in Assisted Reproductive Technologies Treatment Outcome","DW-FET-RCT","Inclusion Criteria:\n\n* Plan to undergo single embryo transfer (SET) during the FET cycle.\n* Age between 18 and 45 years.\n* Patients with at least one high-quality blastocyst available for transfer.\n* Patients who have provided informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with repeated implantation failure (RIF) or recurrent miscarriage (RM).\n* Patients with known uterine anomalies or significant uterine pathology (e.g., fibroids, polyps).\n* Patients who are unwilling or unable to provide informed consent.","FEMALE","18 Years","45 Years",{"count":94,"type":95},578,"ESTIMATED","INTERVENTIONAL",[98],"NA","The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments. The main questions it aims to answer are:\n\n* Does the direct warming method achieve a similar or higher clinical success rate for FET compared to the conventional multi-step method?\n* Is the direct warming method more cost-effective than the conventional method?\n\nResearchers will compare the direct warming method to the conventional multi-step method to see if the former leads to better pregnancy outcomes and reduced procedural time.\n\nParticipants will:\n\n* Undergo either the one-step or conventional embryo thawing procedure.\n* Complete standard clinical follow-ups for pregnancy, including ultrasound scans and pregnancy tests.",[101,102,103,104,105],"Frozen Embryo Transfer (FET)","Assisted Reproductive Techniques","In Vitro Fertilization (IVF)","Cryopreservation of Embryos","Pregnancy Outcome After in Vitro Fertilization (IVF)",[22,107,108,109,110,111,112],"Frozen Embryo Transfer","Assisted Reproductive Technologies","Cryopreservation","Cost-effectiveness in ART","Embryo Warming","In Vitro Fertilization","NOT_YET_RECRUITING","2025-03-06",{"date":116,"type":117},"2025-03-11","ACTUAL",{"date":119,"type":95},"2025-09-01",{"date":121,"type":95},"2027-10-31",{"name":5,"class":6},3]