[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618849":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":10,"responsibleParty":29,"collaborators":10,"id":34,"slug":10,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":10,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":10,"maxAge":10,"enrollmentInfo":41,"targetDuration":10,"studyType":44,"phases":10,"briefSummary":45,"conditions":46,"keywords":49,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":10},{"fullName":5,"class":6},"Hôpital Necker-Enfants Malades","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"wolfram syndrome",null,"Patients according to the EuroWABB criterions of Wolfram syndrome and French national guidelines",[13],"Other: analyse study",{"label":15,"type":10,"description":16,"interventionNames":17},"recessive optic atrophy","patients with an OA due to mutation of gene WFS1, whatever its age of occurrence, without any other clinical manifestation.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"analyse study","Retrospective analyse and study of recorded data of patients with wolfram syndrome or recessive optic atrophy due to WFS1 mutation",[15,9],[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"christophe orssaud, MD","CONTACT","33 1 56 09 34 66","christophe.orssaud@aphp.fr",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":33,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Christophe Orssaud","MD, Responsible CRMR Ophtara HEGP","European Georges Pompidou Hospital","100618849",false,"NCT07336966","Does Recessive Optic Atrophy Due to WFS1 Exist?","Does Recessive Optic Atrophy Due to WFS1 is a Specific Entity Different From Wolfram Syndrome?","Inclusion Criteria:\n\n* WFS1 mutation\n\nExclusion Criteria:\n\n* WFS2 mutation","ALL",{"count":42,"type":43},45,"ESTIMATED","OBSERVATIONAL","All patients with Wolfram syndrome and recessive optic atrophy due to a mutation of the WFS1 from a single Center were included in a retrospective study. Evolution of the visual acuity since the occurrence of the optic atrophy and its last value, OCT data, genetic data and systemic manifestations were analyzed.",[47,48],"Wolfram Syndrome 1","Optic Atrophies, Hereditary",[50,51,52],"WFS1","Wolfram syndrome","hereditary optic neuropathy","NOT_YET_RECRUITING","2026-01-02",{"date":56,"type":57},"2026-01-13","ACTUAL",{"date":59,"type":43},"2026-02",{"date":61,"type":43},"2026-04",{"name":5,"class":6}]