[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053743":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":11,"overallOfficials":30,"centralContacts":38,"locations":44,"responsibleParty":480,"collaborators":482,"id":486,"slug":11,"hasResults":487,"nctId":488,"briefTitle":489,"officialTitle":489,"acronym":490,"eligibilityCriteria":491,"healthyVolunteers":492,"sex":493,"minAge":494,"maxAge":11,"enrollmentInfo":495,"targetDuration":11,"studyType":498,"phases":11,"briefSummary":499,"conditions":500,"keywords":502,"overallStatus":47,"whyStopped":11,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":517,"locationsCount":518},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Positive predictive power of a biomarker or group of biomarkers",null,"Variable follow-up assessment based on age in relation to age at onset of affected parent.",{"measure":14,"description":11,"timeFrame":15},"Biomarkers obtained by blood draw, lumbar puncture, MRI, FDG PET, PET amyloid imaging","Variable follow-up assessment based on age in relation to age at onset of affected parent",{"measure":17,"description":11,"timeFrame":15},"Clinical markers also examined from clinical interview and cognitive testing",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":19,"timePerspective":20,"maskingInfo":11},"COHORT","PROSPECTIVE","Dominantly inherited Alzheimer's disease (AD) represents less than 1% of all cases of AD and is an important model for study because the responsible mutations have known biochemical consequences that are believed to underlie the pathological basis of the disorder. Three major hypotheses will be tested:\n\n* First, that there is a period of preclinical (presymptomatic) AD in individuals who are destined to develop early-onset dementia (gene carriers) that can be detected by changes in biological fluids and in neuroimaging correlates in comparison with individuals who will not develop early-onset dementia (non-carriers).\n* Second, because all identified causative mutations for AD affect the normal processing of amyloid precursor protein (APP) and increase brain levels of amyloid-beta 42 (Aβ42), the sequence of preclinical changes initially will involve Aβ42 (production and clearance; reduced levels in cerebrospinal fluid \\[CSF\\]), followed by evidence for cerebral deposition of Aβ42 (amyloid imaging), followed by cerebral metabolic activity (functional imaging), and finally by regional atrophy (structural imaging).\n* Finally, that the phenotype of symptomatic early-onset familial AD, including its clinical course, is similar to that of late-onset \"sporadic\" AD.\n\nThe following specific aims will be used to test these hypotheses:\n\n1. Maintain the established international DIAN registry of individuals (MCs and non-carriers (NC), symptomatic and asymptomatic) who are biological adult children of an affected parent with an APP, PSEN1, or PSEN2 mutation causing AD and assess participants every 2 years with the uniform DIAN protocol.\n2. Recruit to the registry 50 new asymptomatic participants, both MCs and NCs, in Year 1 of the next budget period to maintain the total DIAN cohort at \\~250 individuals. These new participants will include those who are more than 15 years younger than the estimated age of symptomatic onset (EAO) to explore the earliest observable biomarker changes of preclinical AD.\n3. Maintain the integrated DIAN database and biospecimen repository to disseminate data and tissue to qualified investigators (within and outside of DIAN) in a user-friendly manner and to permit analyses within, between, and among the various data domains that will include:\n\n   1. In asymptomatic MCs (using NCs as controls), determine the temporal ordering and rate of intraindividual change in clinical, cognitive, imaging, and fluid biomarkers of AD prior to EAO\n   2. In symptomatic MCs, compare the clinical and neuropathological phenotypes of ADAD to those of LOAD, using datasets such as ADNI.\n4. Utilize the DIAN cohort and its database and biospecimen repository to support new scientific studies, including use of exome chip technology to examine potential modifiers of age at symptomatic onset. Pursue other new scientific initiatives that are funded independently of the DIAN grant but are conducted within the DIAN infrastructure at no cost to DIAN including: Dermal fibroblasts and induced pluripotent stem cells (iPSCs), examine biomarker surrogates for neurogeneration in CSF including Visinin-like protein-1 (VILIP-1), Tau seeding assay, Stable Isotope Leucine Kinetics (SILK) in DIAN participants, determine the exact Abeta species that underlie AD pathology using Mass spectrometry, exome sequencing on all DIAN participants to search for both positive and negative modifiers of EYO, and amyloid imaging crossover to \\[18F\\]florbetapir.\n5. Provide genetic counseling to any and all DIAN participants who wish to learn their mutation status and, for those who decide to learn their status after counseling, provide genetic testing by Clinical Laboratory Improvement Amendments (CLIA)-approved laboratories (i.e., outside of DIAN).","Mutation carriers and non-carriers from families with a mutation (which is different from the genetic risk factor Apo-E4) known to cause Alzheimer's disease.",[24,27],{"label":25,"type":11,"description":26,"interventionNames":11},"1","Mutation Positive",{"label":28,"type":11,"description":29,"interventionNames":11},"2","Mutation Negative",[31,34],{"name":32,"affiliation":5,"role":33},"Eric McDade, DO","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":36,"role":37},"Alisha Daniels, MD,MHA","(314) 273-9057","STUDY_DIRECTOR",[39,41],{"name":35,"role":40,"phone":36,"phoneExt":11,"email":11},"CONTACT",{"name":42,"role":40,"phone":11,"phoneExt":11,"email":43},"DIAN Obs Admin Core","NEURO-DIANCoordinatingCenter@email.wustl.edu",[45,68,85,104,123,133,150,167,186,203,216,237,247,267,287,306,322,339,354,373,381,395,415,432,450,462],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Mayo Clinic Jacksonville","RECRUITING","Jacksonville","Florida","32224","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-81.65565,30.33218,{"lat":57,"lon":56},[60,63,66],{"name":61,"role":40,"phone":11,"phoneExt":11,"email":62},"Ercilia Moncayo","Moncayo.Ercilia@mayo.edu",{"name":64,"role":40,"phone":11,"phoneExt":11,"email":65},"Twila Morrell, BS","Morrell.Twila@mayo.edu",{"name":67,"role":33,"phone":11,"phoneExt":11,"email":11},"Gregory S Day, MD",{"facility":69,"status":47,"city":70,"state":71,"zip":72,"country":51,"countryCode":52,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Indiana University-Indiana Alzheimer Disease Center","Indianapolis","Indiana","46202",{"type":54,"coordinates":74},[75,76],-86.15804,39.76838,{"lat":76,"lon":75},[79,83],{"name":80,"role":40,"phone":81,"phoneExt":11,"email":82},"Jill Buck, RN","317-963-1847","jilmbuck@iu.edu",{"name":84,"role":33,"phone":11,"phoneExt":11,"email":11},"Martin Farlow, MD",{"facility":86,"status":47,"city":87,"state":88,"zip":89,"country":51,"countryCode":52,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Brigham and Women's Hospital","Boston","Massachusetts","02115",{"type":54,"coordinates":91},[92,93],-71.05977,42.35843,{"lat":93,"lon":92},[96,99,102],{"name":97,"role":40,"phone":11,"phoneExt":11,"email":98},"Alexa Coussoule","acoussoule@bwh.harvard.edu",{"name":100,"role":40,"phone":11,"phoneExt":11,"email":101},"Paola Matos","pmatos1@mgh.harvard.edu",{"name":103,"role":33,"phone":11,"phoneExt":11,"email":11},"Jasmeer Chhatwal, MD, PhD",{"facility":105,"status":47,"city":106,"state":107,"zip":108,"country":51,"countryCode":52,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Washington University in St. Louis School of Medicine","St Louis","Missouri","63108",{"type":54,"coordinates":110},[111,112],-90.19789,38.62727,{"lat":112,"lon":111},[115,118,121],{"name":116,"role":40,"phone":11,"phoneExt":11,"email":117},"McCrae Johnson, RN, MSN","mccrae@wustl.edu",{"name":119,"role":40,"phone":11,"phoneExt":11,"email":120},"Georgia Stobbs-Cucchi, RN","gstobbs@wustl.edu",{"name":122,"role":33,"phone":11,"phoneExt":11,"email":11},"Randall Bateman, MD",{"facility":124,"status":125,"city":126,"state":126,"zip":127,"country":51,"countryCode":52,"cosmosGeoPoint":128,"geoPoint":132,"contacts":11},"Columbia University","SUSPENDED","New York","10032",{"type":54,"coordinates":129},[130,131],-74.00597,40.71427,{"lat":131,"lon":130},{"facility":134,"status":47,"city":135,"state":136,"zip":137,"country":51,"countryCode":52,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"University of Pittsburgh","Pittsburgh","Pennsylvania","15260",{"type":54,"coordinates":139},[140,141],-79.99589,40.44062,{"lat":141,"lon":140},[144,148],{"name":145,"role":40,"phone":146,"phoneExt":11,"email":147},"Zana Ikonomovic, MD","412-692-2740","ikonomovics@upmc.edu",{"name":149,"role":33,"phone":11,"phoneExt":11,"email":11},"Sarah Berman, MD, PhD",{"facility":151,"status":47,"city":152,"state":153,"zip":154,"country":51,"countryCode":52,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Butler Hospital","Providence","Rhode Island","02906",{"type":54,"coordinates":156},[157,158],-71.41283,41.82399,{"lat":158,"lon":157},[161,165],{"name":162,"role":40,"phone":163,"phoneExt":11,"email":164},"Courtney Bodge, PhD","(401) 455-6403","cbodge@butler.org",{"name":166,"role":33,"phone":11,"phoneExt":11,"email":11},"Edward Huey, MD",{"facility":168,"status":47,"city":169,"state":170,"zip":171,"country":51,"countryCode":52,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"University of Washington","Seattle","Washington","98195",{"type":54,"coordinates":173},[174,175],-122.33207,47.60621,{"lat":175,"lon":174},[178,181,184],{"name":179,"role":40,"phone":11,"phoneExt":11,"email":180},"Sarah Taylor","saraht73@uw.edu",{"name":182,"role":40,"phone":11,"phoneExt":11,"email":183},"Emmaline Seth","emmaseth@uw.edu",{"name":185,"role":33,"phone":11,"phoneExt":11,"email":11},"Suman Jayadev, MD",{"facility":187,"status":47,"city":188,"state":189,"zip":11,"country":190,"countryCode":191,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI)","Salta","Salta Province","Argentina","AR",{"type":54,"coordinates":193},[194,195],-65.41999,-24.80645,{"lat":195,"lon":194},[198,201],{"name":199,"role":40,"phone":11,"phoneExt":11,"email":200},"Patricio Chrem","pchremmendez@fleni.org.ar",{"name":202,"role":33,"phone":11,"phoneExt":11,"email":11},"Ricardo Allegri, MD, PhD",{"facility":204,"status":47,"city":205,"state":11,"zip":11,"country":190,"countryCode":191,"cosmosGeoPoint":206,"geoPoint":210,"contacts":211},"Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia\" (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa","Buenos Aires",{"type":54,"coordinates":207},[208,209],-58.37723,-34.61315,{"lat":209,"lon":208},[212,215],{"name":213,"role":40,"phone":214,"phoneExt":11,"email":200},"Patricio Chrem, MD","20565342",{"name":202,"role":33,"phone":11,"phoneExt":11,"email":11},{"facility":217,"status":47,"city":218,"state":219,"zip":220,"country":221,"countryCode":222,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"Neuroscience Research Australia","Sydney","New South Wales","2031","Australia","AU",{"type":54,"coordinates":224},[225,226],151.20732,-33.86785,{"lat":226,"lon":225},[229,232,235],{"name":230,"role":40,"phone":11,"phoneExt":11,"email":231},"Jacob Bechara","j.bechara@neura.edu.au",{"name":233,"role":40,"phone":11,"phoneExt":11,"email":234},"William Brooks, MBBS, MPH","w.brooks@NeuRA.edu.au",{"name":236,"role":33,"phone":11,"phoneExt":11,"email":11},"Emma Devenney, PhD, FRACP",{"facility":238,"status":125,"city":239,"state":240,"zip":241,"country":221,"countryCode":222,"cosmosGeoPoint":242,"geoPoint":246,"contacts":11},"Mental Health Research Institute, University of Melbourne","Melbourne","Victoria","3130",{"type":54,"coordinates":243},[244,245],144.96332,-37.814,{"lat":245,"lon":244},{"facility":248,"status":47,"city":249,"state":250,"zip":251,"country":221,"countryCode":222,"cosmosGeoPoint":252,"geoPoint":256,"contacts":257},"Sir James McCusker Alzheimer's Disease Research Unit, Edith Cowan University","Perth","Western Australia","6009",{"type":54,"coordinates":253},[254,255],115.8614,-31.95224,{"lat":255,"lon":254},[258,262,265],{"name":259,"role":40,"phone":260,"phoneExt":11,"email":261},"Kevin Taddei","+61-(0)8-6304-5107","k.taddei@ecu.edu.au",{"name":263,"role":40,"phone":11,"phoneExt":11,"email":264},"Samantha Gardener","s.gardener@ecu.edu.au",{"name":266,"role":33,"phone":11,"phoneExt":11,"email":11},"Ralph Martins, PhD",{"facility":268,"status":47,"city":269,"state":269,"zip":270,"country":271,"countryCode":272,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo","São Paulo","05403-900","Brazil","BR",{"type":54,"coordinates":274},[275,276],-46.63611,-23.5475,{"lat":276,"lon":275},[279,282,285],{"name":280,"role":40,"phone":11,"phoneExt":11,"email":281},"Aline Nishizawa","anishizawa1@gmail.com",{"name":283,"role":40,"phone":11,"phoneExt":11,"email":284},"Carreira Luzia Lima","luzia.carreira@hc.fm.usp.br",{"name":286,"role":33,"phone":11,"phoneExt":11,"email":11},"Leonel Tadao Takada, MD, PHD",{"facility":288,"status":289,"city":290,"state":291,"zip":292,"country":293,"countryCode":294,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"McGill University Research Centre for Studies in Aging","NOT_YET_RECRUITING","Verdun","Quebec","H4H 1R3","Canada","CA",{"type":54,"coordinates":296},[297,298],-73.57058,45.46005,{"lat":298,"lon":297},[301,304],{"name":302,"role":40,"phone":11,"phoneExt":11,"email":303},"Tamar Tatigian","tamar.tatigian@mcgill.ca",{"name":305,"role":33,"phone":11,"phoneExt":11,"email":11},"Pedro Rosa-Neto, MD,PhD",{"facility":307,"status":47,"city":308,"state":309,"zip":11,"country":309,"countryCode":310,"cosmosGeoPoint":311,"geoPoint":315,"contacts":316},"Grupo Neurociencias de Antioquia","Medellín","Colombia","CO",{"type":54,"coordinates":312},[313,314],-75.57151,6.245,{"lat":314,"lon":313},[317,320],{"name":318,"role":40,"phone":11,"phoneExt":11,"email":319},"Yudy Milena León Varela","yudy.leon@gna.org.co",{"name":321,"role":33,"phone":11,"phoneExt":11,"email":11},"David Aguillon, MD",{"facility":323,"status":47,"city":324,"state":11,"zip":325,"country":326,"countryCode":327,"cosmosGeoPoint":328,"geoPoint":332,"contacts":333},"German Center for Neurodegenerative Diseases (DZNE) Munich, and University Hospital Ludwig-Maximilians-Universitat (LMU) Munich","Munich","D-81377","Germany","DE",{"type":54,"coordinates":329},[330,331],11.57549,48.13743,{"lat":331,"lon":330},[334,337],{"name":335,"role":40,"phone":11,"phoneExt":11,"email":336},"Ilona Ruge","Ilona.Ruge@dzne.de",{"name":338,"role":33,"phone":11,"phoneExt":11,"email":11},"Johannes Levin, MD, PhD",{"facility":340,"status":47,"city":341,"state":11,"zip":342,"country":326,"countryCode":327,"cosmosGeoPoint":343,"geoPoint":347,"contacts":348},"German Center for Neurodegenerative Diseases (DZNE) Tübingen and Hertie-Institute for Clinical Brain Research, University of Tübingen","Tübingen","D-72076",{"type":54,"coordinates":344},[345,346],9.05222,48.52266,{"lat":346,"lon":345},[349,352],{"name":350,"role":40,"phone":11,"phoneExt":11,"email":351},"Beatrice Spring","beatrice.spring@med.uni-tuebingen.de",{"name":353,"role":33,"phone":11,"phoneExt":11,"email":11},"Mathias Jucker, PhD",{"facility":355,"status":47,"city":356,"state":11,"zip":11,"country":357,"countryCode":358,"cosmosGeoPoint":359,"geoPoint":363,"contacts":364},"Niigata University","Niigata","Japan","JP",{"type":54,"coordinates":360},[361,362],139.04125,37.92259,{"lat":362,"lon":361},[365,368,371],{"name":366,"role":40,"phone":11,"phoneExt":11,"email":367},"Sumie Tsuruki","sumietsuruki@bri.niigata-u.ac.jp",{"name":369,"role":40,"phone":11,"phoneExt":11,"email":370},"Maki Watanabe","m-watanabe@iris-aumn.co.jp",{"name":372,"role":33,"phone":11,"phoneExt":11,"email":11},"Takeshi Ikeuchi, MD",{"facility":374,"status":125,"city":375,"state":11,"zip":11,"country":357,"countryCode":358,"cosmosGeoPoint":376,"geoPoint":380,"contacts":11},"Osaka City University","Osaka",{"type":54,"coordinates":377},[378,379],135.50107,34.69379,{"lat":379,"lon":378},{"facility":382,"status":47,"city":383,"state":11,"zip":11,"country":357,"countryCode":358,"cosmosGeoPoint":384,"geoPoint":388,"contacts":389},"Tokyo University","Tokyo",{"type":54,"coordinates":385},[386,387],139.69171,35.6895,{"lat":387,"lon":386},[390,393],{"name":391,"role":40,"phone":11,"phoneExt":11,"email":392},"Haruko Kuzuyamah","kuzuyamah@g.ecc.u-tokyo.ac.jp",{"name":394,"role":33,"phone":11,"phoneExt":11,"email":11},"Yoshiki Niimi, MD",{"facility":396,"status":47,"city":397,"state":397,"zip":398,"country":399,"countryCode":400,"cosmosGeoPoint":401,"geoPoint":405,"contacts":406},"Instituto Nacional de Neurología y Neurocirugía \"Manuel Velasco Suarez\"","Mexico City","14269","Mexico","MX",{"type":54,"coordinates":402},[403,404],-99.12766,19.42847,{"lat":404,"lon":403},[407,410,412],{"name":408,"role":40,"phone":11,"phoneExt":11,"email":409},"Gabriela Rojas de la Torre, MS, MA","gabriella.delatorre.1066@gmail.com",{"name":411,"role":33,"phone":11,"phoneExt":11,"email":11},"Ana Luisa Sosa Ortiz, PHD",{"name":413,"role":414,"phone":11,"phoneExt":11,"email":11},"Erika Mariana Longoria Ibarrola, MD","SUB_INVESTIGATOR",{"facility":416,"status":47,"city":417,"state":11,"zip":418,"country":419,"countryCode":420,"cosmosGeoPoint":421,"geoPoint":425,"contacts":426},"Amsterdam UMC","Amsterdam","1081HV","Netherlands","NL",{"type":54,"coordinates":422},[423,424],4.88969,52.37403,{"lat":424,"lon":423},[427,430],{"name":428,"role":40,"phone":11,"phoneExt":11,"email":429},"Bram Bongers","b.bongers@amsterdamumc.nl",{"name":431,"role":33,"phone":11,"phoneExt":11,"email":11},"Lisa Vermunt, MD,PhD",{"facility":433,"status":47,"city":434,"state":435,"zip":436,"country":437,"countryCode":11,"cosmosGeoPoint":438,"geoPoint":442,"contacts":443},"Asan Medical Center","Seoul","Songpa-Gu","05505","South Korea",{"type":54,"coordinates":439},[440,441],126.9784,37.566,{"lat":441,"lon":440},[444,448],{"name":445,"role":40,"phone":446,"phoneExt":11,"email":447},"Jee Hoon Roh, MD, PhD","82-2-3010-3443","roh@amc.seoul.kr",{"name":449,"role":33,"phone":11,"phoneExt":11,"email":11},"Jae Hong Lee, MD, PhD",{"facility":451,"status":125,"city":452,"state":453,"zip":454,"country":455,"countryCode":456,"cosmosGeoPoint":457,"geoPoint":461,"contacts":11},"Hospital Clinic Barcelona","Barcelona","Catalonia","08036","Spain","ES",{"type":54,"coordinates":458},[459,460],2.15899,41.38879,{"lat":460,"lon":459},{"facility":463,"status":47,"city":464,"state":11,"zip":465,"country":466,"countryCode":467,"cosmosGeoPoint":468,"geoPoint":472,"contacts":473},"Institute of Neurology, Queen Square","London","WC1N 3BG","United Kingdom","UK",{"type":54,"coordinates":469},[470,471],-0.12574,51.50853,{"lat":471,"lon":470},[474,478],{"name":475,"role":40,"phone":476,"phoneExt":11,"email":477},"Helen Rice, RN","07741 671 840","helen.rice2@nhs.net",{"name":479,"role":33,"phone":11,"phoneExt":11,"email":11},"Nick Fox, MD",{"type":481,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[483],{"name":484,"class":485},"National Institute on Aging (NIA)","NIH","100053743",false,"NCT00869817","Dominantly Inherited Alzheimer Network (DIAN)","DIAN","Inclusion Criteria:\n\n* Written informed consent obtained from participant and collateral source prior to any study-related procedures.\n* Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.\n* Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.\n* Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.\n* Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.\n\nExclusion Criteria:\n\n* Under age 18\n* Medical or psychiatric illness that would interfere in completing initial and follow-up visits\n* Requires nursing home level care\n* Has no one who can serve as a study informant",true,"ALL","18 Years",{"count":496,"type":497},700,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.",[501],"Alzheimer's Disease",[503,504,505,506,507,508],"Alzheimer's disease","antecedent biomarkers","Amyloid Precursor Protein (APP) mutation","presenilin I (PS1) mutation","presenilin 2 (PS2) mutation","Autosomal Dominant Alzheimer's Disease","2026-07-10",{"date":511,"type":512},"2026-07-13","ACTUAL",{"date":514,"type":11},"2009-01",{"date":516,"type":497},"2027-07",{"name":5,"class":6},26]