Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
ConditionSevere Asthma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorBastiaan Driehuys
About this trial
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Eligibility criteria
Qualifiers
Adequate completion of informed consent process with written documentation
Patients 18 - 65 years old
Physician diagnosis of asthma for > 1 year
Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs within previous 30 days of enrollment
Disqualifiers
Respiratory tract infection within the 4 weeks prior to Visit 1
Body mass index (BMI) > 30 at Visit 1
One-time doses such as intra-articular injections require a 4-week washout prior to Visit 1
Asthma-related ER visit within the previous 4 weeks of Visit 1 or at any time while on the study
Trial design
Treatments tested in this trial
- Hyperpolarized Xenon 129
Treatment groups
No treatment groups listed
Sponsors and collaborators
Bastiaan Driehuys
Lead sponsor
Duke University
Sponsor institution
University of Kansas Medical Center
Collaborator
Polarean, Inc.
Collaborator
Source ClinicalTrials.gov