About this trial
Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Active duty military
18-55 years old
Over 6 months remaining at local duty station
Disqualifiers
Tobacco user
Medications that affect soft tissue or bone healing
Metabolic disorder that affects soft tissue or bone healing
Active periodontal disease
Trial design
Single group
Treatments tested in this trial
Chlorhexidine
DrugChlorhexidine will be inserted into the dental implant internal cavity during dental implant insertion.
Hydrogen Peroxide
DrugHydrogen Peroxide will be inserted into the internal cavity of the dental implant during dental implant insertion.
Treatment groups
Trial outcomes
Primary outcomes
Implant Failure
We will compare the rates of dental implant failure between study arms.
Secondary outcomes
Peri-Implantitis
We will compare the rates of peri-implantitis between study arms.
Bacterial Load
We will compare the bacterial load in the dental implant internal cavity between study arms.
Microbiome Composition
We will compare the relative abundance of red and orange complex bacteria in the dental implant internal cavity between study arms.
Sponsors and contacts
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Madigan Army Medical Center
Lead sponsor
United States Department of Defense
Collaborator