[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100493458":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":58,"collaborators":60,"id":67,"slug":40,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":40,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":44,"whyStopped":40,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"The University of Texas Health Science Center at San Antonio","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment group Valine then EEA","EXPERIMENTAL","Valine will be administered as two 4 gm packets administered on dialysis treatment day followed by a washout period and then EEA",[13,14],"Drug: Valine","Drug: EEA",{"label":16,"type":10,"description":17,"interventionNames":18},"Treatment group EEA then Valine","EAA will be administered as one 12.5 gm packet administered on dialysis treatment day followed by a washout and then Valine",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Valine","A medical food intended for use under medical supervision",[16,9],[26],"Valine Amino Acid Supplement",{"type":21,"name":28,"description":23,"armGroupLabels":29,"otherNames":30},"EEA",[16,9],[31],"Essential Amino Acid Supplement",[33],{"name":34,"affiliation":5,"role":35},"Subrata Debnath, PhD","PRINCIPAL_INVESTIGATOR",[37],{"name":34,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","210-567-4700",null,"nath@uthscsa.edu",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","San Antonio","Texas","78229","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-98.49363,29.42412,{"lat":54,"lon":53},[57],{"name":34,"role":38,"phone":39,"phoneExt":40,"email":41},{"type":59,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR",[61,64],{"name":62,"class":63},"National Center for Advancing Translational Sciences (NCATS)","NIH",{"name":65,"class":66},"IIMS-UT Health San Antonio","UNKNOWN","100493458",false,"NCT05705414","Oral Intradialytic Amino Acid Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis","Oral Intradialytic Amino Acids Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis (OASIS)","OASIS","Inclusion Criteria:\n\n1. Male or Female\n2. Age 18-64 years\n3. Receiving 3 x weekly in clinic hemodialysis for at least 6 months\n\nExclusion Criteria:\n\n1. Hypersensitivity to amino acid(s) and\u002For any excipient\n2. Clinical documentation of COVID-19\n3. Concomitant intake of amino acids supplements\n4. Current use or abuse of alcohol, marijuana, narcotic, or other substances\n5. Heart failure receiving active management\n6. Malignant cancer receiving anticancer therapy\n7. Diagnosis of major depressive disorder receiving antidepressants\n8. Diagnosis of chronic liver disease\n9. Cerebrovascular disease with sequelae\n10. Upper limb amputation, osteoarthritis, or degenerative diseases of fingers, carpel tunnel syndrome in the non-fistula or graft hand preventing completion of hand grip strength test.","ALL","18 Years","64 Years",{"count":78,"type":79},28,"ESTIMATED","INTERVENTIONAL",[82],"EARLY_PHASE1","The study will test and compare the efficacy of a single essential amino acid valine with a combination of essential amino acids (EAA) supplement on fatigue, frailty, and cognitive function in end-stage kidney disease (ESKD) patients undergoing hemodialysis (HD) treatment.",[85],"End Stage Renal Disease",[87,88,89],"Fatigue","End-stage kidney disease","Hemodialysis","2026-01-02",{"date":92,"type":93},"2026-01-06","ACTUAL",{"date":95,"type":93},"2024-10-18",{"date":97,"type":79},"2026-12",{"name":5,"class":6},1]