Through a prospective randomized controlled trial, we systematically evaluate the effects of Yiqi Huoxue Jiedu Formula combined with bacteriophage therapy on the bacterial clearance rate, disease improvement rate and mortality rate in patients with severe pneumonia caused by drug-resistant bacteria, so as to clarify its clinical transformation value.
Patients who meet the diagnostic criteria for severe pneumonia caused by drug-resistant Gram-negative bacilli and conform to the TCM syndrome differentiation of Qi deficiency, toxin accumulation and blood stasis syndrome;
Patients confirmed by rapid on-site microbiological evaluation (M-ROSE), clinical microbial culture and drug susceptibility testing (based on the drug susceptibility test results of our hospital or other Grade A tertiary hospitals) to be infected with multidrug-resistant Klebsiella pneumoniae, Acinetobacter baumannii or Pseudomonas aeruginosa;
Aged 18 to 85 years old;
Patients or their family members agree to cooperate with the collection of upper and lower respiratory tract specimens, consent to bronchoscopy plus bronchoalveolar lavage, and agree to receive nebulized inhalation of bacteriophage therapy;
Women who are pregnant or lactating;
Patients with immunodeficiency;
Patients receiving immunosuppressive therapy or suffering from immunodeficiency diseases;
Patients who have received mechanical ventilation for more than 60 days prior to enrollment;
Parallel
YHDF placebo
Drug7-14 days treatment with YHDF placebo
Bacteriophage Placebo
Drug7-14 days treatment with bacteriophage placebo
YHDF Drug
Drug7-14 days treatment with YHDF
Bacteriophage
Drug7-14 days treatment with bacteriophage
Clearance rate of drug-resistant bacteria
Time to clinical improvement
All-cause mortality
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
