[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636062":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":34,"locations":40,"responsibleParty":56,"collaborators":33,"id":60,"slug":33,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":33,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":91,"whyStopped":33,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Oxford Brookes University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Beetroot Juice Then Placebo","EXPERIMENTAL","Participants receive nitrate-rich beetroot juice during the first visit and a nitrate-depleted placebo during the second visit, with a washout period of at least 48 hours between visits.",[13,14],"Dietary Supplement: Beetroot juice","Dietary Supplement: Nitrate-depleted Beetroot Juice Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Placebo Then Beetroot Juice","Participants receive a nitrate-depleted placebo during the first visit and nitrate-rich beetroot juice during the second visit, with a washout period of at least 48 hours between visits.",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Beetroot juice","A single dose of approximately 70 mL of nitrate-rich beetroot juice providing approximately 400 mg of inorganic nitrate will be administered. The product consists of concentrated beetroot juice with a small amount of lemon juice and is consumed prior to exercise testing. The timing of ingestion is standardized to allow peak nitrate-nitrite-nitric oxide conversion within approximately 2 to 3 hours. This intervention is intended to increase nitric oxide bioavailability and assess its acute effects on cardiovascular and autonomic responses.",[9,16],[26],"Nitrate-rich beetroot juice",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Nitrate-depleted Beetroot Juice Placebo","A nitrate-depleted beetroot juice placebo matched for appearance, taste and packaging will be administered in a single dose of approximately 70 mL. The placebo is identical to the active intervention in all aspects except for nitrate content. It is consumed under the same standardized conditions and timing as the active intervention to maintain blinding and allow controlled comparison of physiological responses.",[9,16],[32],"Placebo beetroot juice",null,[35],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"Bruno M Candeloro, MSc","CONTACT","+447523113252","diabeet.study@brookes.ac.uk",[41],{"facility":42,"status":33,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Clinical Physiology Laboratory, Oxford Brookes University","Oxford","Oxfordshire","OX3 0BP","United Kingdom","UK",{"type":49,"coordinates":50},"Point",[51,52],-1.25596,51.75222,{"lat":52,"lon":51},[55],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Dr. Shakeeb H Moosavi","Principal Investigator","100636062",false,"NCT07560800","Effect of Beetroot Juice on Cardiovascular and Autonomic Responses to Exercise in Adults With Type 2 Diabetes","Effect of Beetroot Juice on Cardiovascular and Autonomic Responses During and After Exercise in Adults With Type 2 Diabetes","DiaBEET","Inclusion Criteria:\n\n* Clinically diagnosed Type 2 Diabetes Mellitus\n* Aged 40 to 65 years\n* Not treated with insulin\n* Stable diabetes medication regimen for at least 3 months\n* Able to understand the study information and provide informed consent\n* Able to safely perform light-to-moderate cycling exercise\n\nExclusion Criteria:\n\n* Current or recent use of insulin\n* Use of organic nitrates (e.g., glyceryl trinitrate) or phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil)\n* Use of systemic antibiotics within the specified preparation period or regular use of antiseptic\u002Fantibacterial mouthwash during study participation\n* Use of supplements known to interfere with nitric oxide metabolism within the defined preparation period\n* Unstable or clinically significant cardiovascular disease\n* Uncontrolled hypertension or any condition that makes exercise unsafe\n* Chronic kidney disease, history of kidney stones, or other relevant renal conditions\n* Neurological, musculoskeletal or systemic disorders that impair safe participation\n* Known or suspected allergy or intolerance to beetroot, lemon or any component of the study products\n* Pregnancy or breastfeeding\n* Inability to comply with study preparation requirements","ALL","40 Years","65 Years",{"count":71,"type":72},20,"ESTIMATED","INTERVENTIONAL",[75],"NA","This study will investigate whether a single dose of beetroot juice can improve cardiovascular responses and recovery after exercise in adults with Type 2 Diabetes.\n\nType 2 Diabetes is associated with higher blood pressure, impaired blood vessel function, and reduced autonomic control of the heart, all of which increase cardiovascular risk and may affect how the body responds to and recovers from physical activity. Beetroot juice is naturally rich in dietary nitrate, which is converted in the body into nitric oxide, a molecule that helps blood vessels relax and improve blood flow. While these effects have been demonstrated in healthy individuals, less is known about their impact in people with Type 2 Diabetes.\n\nIn this study, approximately 16 to 20 adults aged 40 to 65 years with Type 2 Diabetes will take part. After an online screening and consent process, eligible participants will attend two laboratory visits at Oxford Brookes University. In a randomised, double-blind, placebo-controlled crossover design, participants will receive beetroot juice during one visit and a nitrate-depleted placebo during the other visit.\n\nDuring each visit, participants will undergo physiological measurements, including blood pressure, heart rate, oxygen saturation, and capillary blood glucose. Participants will then complete a short session of supervised, light-to-moderate cycling exercise. Measurements will continue during the recovery period to assess how quickly the cardiovascular system returns to resting levels.\n\nThe main outcomes are systolic blood pressure and heart rate variability during recovery, which reflect cardiovascular regulation and autonomic function. Secondary outcomes include diastolic blood pressure, heart rate, blood glucose, and markers related to nitric oxide availability.\n\nThis study may help determine whether a simple, dietary-based intervention such as beetroot juice can support cardiovascular function and improve recovery after exercise in people living with Type 2 Diabetes.",[78,79,80],"Type 2 Diabetes Mellitus","Hypertension","Autonomic Nervous System Diseases",[22,82,83,84,85,86,87,88,89,90],"Dietary nitrate","Nitric oxide","Heart rate variability","Autonomic function","Blood pressure","Exercise recovery","Submaximal exercise","Endothelial function","Crossover trial","NOT_YET_RECRUITING","2026-04-28",{"date":94,"type":95},"2026-05-01","ACTUAL",{"date":97,"type":72},"2026-04-02",{"date":99,"type":72},"2026-07-31",{"name":5,"class":6},1]