Effect of Different Meal Types Given Before Exercise on Plasma Amino Acid Levels and Metabolic Control Parameters in Classical Phenylketonuria Patients Undergoing Aerobic and Resistance Exercises

ConditionPhenylketonuria

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorHacettepe University

About this trial

This study will be the first in the literature to evaluate the relationship between aerobic and resistance exercises, plasma amino acid levels, metabolic control of patients, and the metabolic response to exercise with different types of meals in patients with Phenylketonuria (PKU). In patients with phenylketonuria, the aim is to determine which pre-exercise dietary recommendations are more physiologically appropriate and ideal for achieving good metabolic control.

In the literature, there are very few studies examining the effects of exercise on plasma amino acid levels and metabolic parameters in PKU patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Be over 18 years old,

Having a classic FKU diagnosis,

Not being actively engaged in sports,

Not having any other existing diseases,

Disqualifiers

Presence of a chronic disease accompanying FKU disease (endocrine, etc.)

The individual with FKU has mental retardation or is deemed unfit for work based on psychomotor assessment,

Recent weight loss, history of hospitalisation, a past infection, or a diagnosed illness

Use of drugs or alcohol that alter protein and energy metabolism (e.g., corticosteroids, etc.)

Trial design

Design model

Crossover

Treatments tested in this trial

Aerobic Exercise
Behavioral
Participants performed 30 minutes of moderate-intensity aerobic exercise on a treadmill at 80% of maximum heart rate with a 3% incline.
Resistance Exercise
Behavioral
Participants performed a resistance exercise session including 3 sets of 10 repetitions of crunch, push-up, forward lunge, and squat exercises.
Water
Other intervention
Participants consumed 200 ml of water prior to the exercise session.
Carbohydrates
Dietary supplement
Participants consumed carbohydrates at a dose of 1 g/kg/hour prior to the exercise session.
Protein
Dietary supplement
Participants consumed protein equivalent to 0.4 g/kg/hour (amino acids) prior to the exercise session.

Treatment groups

10 Participants

are divided into 6 treatment groups

Treatment groups

See each treatment group below.

Group A: Aerobic Exercise + WaterExperimental treatment 2 interventions

Group B: Aerobic Exercise + CarbohydratesExperimental treatment 3 interventions

Group C: Aerobic Exercise + Carbohydrates + ProteinExperimental treatment 4 interventions

Group D: Resistance Exercise + WaterExperimental treatment 2 interventions

Group E: Resistance Exercise + CarbohydratesExperimental treatment 3 interventions

Group F: Resistance Exercise + Carbohydrates + ProteinExperimental treatment 4 interventions

Trial outcomes

Primary outcomes

Change in Plasma Phenylalanine Levels

Venous blood samples will be analyzed to determine changes in plasma phenylalanine concentrations in response to exercise and different pre-exercise meal types.

Time frame