Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorKonya City Hospital
About this trial
Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising healthcare costs.
The incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden.
Effective postoperative pain control is critical not only for maintaining quality of life but also for preserving cognitive well-being. In this context, peripheral nerve blocks are frequently used for pain management following hip surgery.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients aged 18-80
ASA I-III risk groups
Undergoing elective hip surgery
Disqualifiers
Preoperative history of delirium, dementia, or major neurological disease
Present cognitive impairment or severe hearing or visual impairment that could affect pain assessment
Development of mechanical ventilation requirement in the intensive care unit; Need for bilateral hip surgery
Failure to provide meaningful analgesia after block application due to surgical pain outside the scope of the block
Trial population
We conducted a pilot study on 20 patients using the 'goodness-of-fit tests: contingency tables' test with G Power software. In our study, the incidence of rebound pain was 40%, and postoperative delirium developed in 50% of patients with rebound pain, compared to 8.3% in patients without rebound pain. Based on these data, an effect size of 0.356 was found, and an analysis was conducted using α=0.05, 90% power. The sample size was calculated as 83 patients. Considering the dropout rate, a total of 90 patients (36 patients with rebound pain and 54 patients without rebound pain) were calculated to be included in the study.
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Peripheral nerve block applied
Other interventionPericapsular Nerve Group block and the supra-inguinal fascia iliaca block applied
Only multimodal analgesia applied
Other interventionPostoperative analgesia (paracetamol 1000 mg intravenously every 8 hours and celecoxib 200 mg orally every 12 hours)
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Incidence of delirium
The incidence of delirium will be evaluated in the first 72 hours postoperatively in the intensive care unit.
Time frame
72 hoursSponsors and contacts
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Source ClinicalTrials.gov