[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515876":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":61,"collaborators":64,"id":67,"slug":26,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":26,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Universidad Nacional Autonoma de Mexico","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active rTMS frequency at 10 Hz","EXPERIMENTAL","The intervention will be Repetitive Transcranial Magnetic Stimulation. Each patient will receive treatment stimulation in the left dorsolateral prefrontal cortex (lDLPFC) with a frequency of 10 Hz, that includes 2 sessions per day for 20 consecutive business days for 4 weeks. Each session will consist of the application of rTMS at a frequency of 10 Hz, to 100% of the motor threshold. The lDLPFC target will be determined using their resting state functional connectivity between anterior cingulate cortex and lDLPFC. Our algorithm performs a calculation of the individual localization of the participant's lDLPFC, which will be used for the whole study in that particular participant.",[13],"Device: Repetitive Transcranial Magnetic Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham rTMS frequency at 10 Hz","SHAM_COMPARATOR","The intervention will be Repetitive Transcranial Magnetic Stimulation (Sham). For this patients the coil will be located on the vertex. Each patient will receive sham stimulation with a frequency of 10 Hz, that includes 2 sessions per day for 20 consecutive business days for 4 weeks. Each session will consist of the application of rTMS at a frequency of 10 Hz, to 100% of the motor threshold. The lDLPFC target will be determined using their resting state functional connectivity between anterior cingulate cortex and lDLPFC. Our algorithm performs a calculation of the individual localization of the participant's lDLPFC, which will be used for the whole study in that particular participant.",[19],"Device: Repetitive Transcranial Magnetic Stimulation (Sham)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Repetitive Transcranial Magnetic Stimulation","The investigators will use a Magstim Rapid 2 stimulator, Airfilled coil (AFC), 8 shape (magnetic field of 0.8 Teslas, 3Kg, pulse 0.5 ms)\n\nEach patient will receive high frequency 10 Hz stimulation at 100% of motor threshold over the dorsolateral prefrontal cortex (DLPFC) at 1500 pulses per session with 30 trains of 5 seconds and 0.5 ms stimuli and an inter-train distance of 15 seconds. In 2 daily sessions 4 days a week for 4 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Repetitive Transcranial Magnetic Stimulation (Sham)","The investigators will use a Magstim Rapid 2 stimulator, Airfilled coil (AFC), 8 shape (magnetic field of 0.8 Teslas, 3Kg, pulse 0.5 ms)\n\nEach patient will receive consistent treatment in 2 sessions a day for 20 consecutive business days for 4 weeks. The coil will be placed on the vertex target location.",[15],[32],{"name":33,"affiliation":5,"role":34},"Eduardo A Garza-Villarreal, MD, PhD","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Alejandra Lopez Castro, MD, MSc","CONTACT","+524422381038","alejandraloc@comunidad.unam.mx",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Unidad de Resonancia Magnética","RECRUITING","Querétaro City","Querétaro","76230","Mexico","MX",{"type":51,"coordinates":52},"Point",[53,54],-100.38806,20.58806,{"lat":54,"lon":53},[57,59],{"name":37,"role":38,"phone":58,"phoneExt":26,"email":40},"4422381038",{"name":60,"role":34,"phone":26,"phoneExt":26,"email":26},"Eduardo A Garza Villarreal, MD, PhD",{"type":34,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Eduardo Adrian Garza Villarreal","Assistant Professor",[65],{"name":66,"class":6},"National Council of Science and Technology, Mexico","100515876",false,"NCT05997212","Effect of Repetitive TMS on Executive Function in Alcohol Use Disorder","Effect of Repetitive Transcranial Magnetic Stimulation on the Executive Function in Alcohol Use Disorder","Inclusion Criteria:\n\n* Men and women of 25 to 59 years old\n* The reading level of at least 6th grade of primary (equivalent to fifth grade of elementary school).\n* Alcohol users with and AUDIT ≥ 20 puntos\n* Abstinence from alcohol consumption from 8 weeks to 5 years, with CIWA-Ar scale scores ≤ 9 points.\n* No disabling neuropsychiatric conditions (i.e. Schizophrenia)\n* No substance use disorders except alcohol and nicotine.\n* BrAC (Breath Alcohol) = 0.00 mg\u002Fdl in each of the assessments.\n* No traces of alcohol consumption using urine test strips.\n* No contraindications for TMS therapy.\n\nExclusion Criteria:\n\n* Individuals with symptoms of severe agitation or who are unable to cooperate in the study\n* History of epilepsy\n* Sudden onset of stroke, focal neurological findings such as hemiparesis, sensory loss, visual field deficits and lack of coordination.\n* Seizures or gait disturbances\n* History of severe psychiatric disorders.\n* Alterations in a conventional electroencephalogram.\n* Pacemakers or intracranial metallic objects.\n\nElimination criteria\n\n* At the subject's request\n* The presence of adverse incidents that deteriorate the subject's health and would limit continuation of rTMS treatment.\n* Exacerbation of cognitive or behavioral symptoms during treatment.","ALL","25 Years","59 Years",{"count":77,"type":78},44,"ESTIMATED","INTERVENTIONAL",[81],"NA","Alcohol Use Disorder (AUD) is a major public health problem that affects the physical, social, family, and mental integrity of the sufferer. Behavioral self-regulation is compromised in AUD, and a benefit has been reported with the application of repetitive transcranial magnetic stimulation and emotional self-regulation. The aim of this study is to investigate the efficacy of high-frequency rTMS to improve executive functions in patients in abstinence from AUD.",[84],"Alcohol Use Disorder",[86,87,88,89,90,91,92],"mri","rtms","tms","repetitive transcranial magnetic stimulation","mexico","magnetic resonance imaging","executive function","2025-02-06",{"date":95,"type":96},"2025-02-10","ACTUAL",{"date":98,"type":96},"2024-03-16",{"date":100,"type":78},"2026-11-01",{"name":5,"class":6},1]