Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy

ConditionPerioperative Respiratory Mechanics

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-65

SponsorKonya City Hospital

About this trial

This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults aged 18-65 years

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

Sevoflurane
Drug
General anesthesia will be maintained with sevoflurane at 2% concentration in patients assigned to the Sevoflurane Group (Group S). Standardized ventilator settings will be applied for all participants, and mechanical power will be measured at three intraoperative time points while sevoflurane is used as the sole maintenance inhalational agent.
Desflurane
Drug
Maintenance of general anesthesia with desflurane 6% during laparoscopic cholecystectomy. Mechanical power is measured at three intraoperative time points using standardized ventilator settings.

Treatment groups

138 Participants

are divided into 2 treatment groups

Group A: Arm S- Sevoflurane GroupExperimental treatment 1 intervention

Group B: Arm D-desflurane groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Mechanical Power (MP) during General Anesthesia

Time frame

Measured at three intraoperative time points: Post-intubation baseline (MP1) 15 minutes after pneumoperitoneum (MP2) End of surgery before emergence (MP3)

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Konya City Hospital

Lead sponsor

Source ClinicalTrials.gov

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