[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642395":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":36,"locations":29,"responsibleParty":42,"collaborators":29,"id":46,"slug":29,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":29,"eligibilityCriteria":50,"healthyVolunteers":47,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":29,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":66,"whyStopped":29,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":29},{"fullName":5,"class":6},"Hong Kong Metropolitan University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-calorie MIND-HK diet","EXPERIMENTAL","Low-calorie MIND-HK diet is based on the MIND diet originally developed by Morris and colleagues in 2015 (1, 2) and adapted from the Arjmand group's 3-month MIND diet intervention (5). The Low-calorie MIND-HK diet intervention will be a 12-week nutrition program consisting of four in-person nutrition counselling sessions (one session per week, 60 minutes per session and 30 minutes question and answer session) in an activity room at each participating community centre. All sessions will be conducted by a registered nutritionist. In the nutrition sessions, the participants will learn to modify their diet to meet the low-calorie MIND-HK diet guidelines.",[13],"Behavioral: Low-calorie MIND-HK diet",{"label":15,"type":10,"description":16,"interventionNames":17},"Very Low-calorie MIND-HK diet","Very Low-calorie MIND-HK diet is based on the MIND diet originally developed by Morris and colleagues in 2015 (1, 2) and adapted from the Arjmand group's 3-month MIND diet intervention (5). The very Low-calorie MIND-HK diet intervention will be a 12-week nutrition programme consisting of four in-person nutrition counselling sessions (one session per week, 60 minutes per session and 30 minutes question and answer session) in an activity room at each participating community centre. All intervention sessions will be conducted by a registered nutritionist. In the nutrition sessions, the participants will learn to modify their diet to meet the low-calorie diet guidelines. As a reference, a 7-day sample menu that meets the required number of servings per day will be provided. To maintain consistency, one nutritionist and one research assistant, will administer the intervention.",[18],"Behavioral: Very Low-calorie MIND-HK diet",{"label":20,"type":6,"description":21,"interventionNames":22},"Control group","An attention control group will receive the same amount of attention in four in-person infectious disease counselling sessions (one session per week, 60 minutes per session, and a 30- minute question and answer session) (6).",[23],"Other: Control group",[25,30,33],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"BEHAVIORAL","This 12-week community-based lifestyle intervention is designed to help participants modify their daily intake to meet low-calorie MIND-HK dietary guidelines. The program includes four weekly education sessions (60-minute lesson and 30-minute Q\\&A) covering portion control and food groups, alongside continuous monitoring of dietary logs to track compliance and support self-management throughout the study period.",[9],null,{"type":26,"name":15,"description":31,"armGroupLabels":32,"otherNames":29},"This 12-week community-based lifestyle intervention is designed to help participants modify their daily intake to meet very low-calorie MIND-HK dietary guidelines. Administered by a consistent team of one nutritionist and one research assistant to ensure program fidelity, the intervention includes four weekly sessions (60-minute lesson and 30-minute Q\\&A) covering calorie-reduction strategies, alongside the distribution of structured sample menus and continuous tracking to support dietary compliance.",[15],{"type":6,"name":20,"description":34,"armGroupLabels":35,"otherNames":29},"An attention control group will receive the same amount of attention in four in-person infectious disease counselling sessions (one session per week, 60 minutes per session, and a 30- minute question and answer session).",[20],[37],{"name":38,"role":39,"phone":40,"phoneExt":29,"email":41},"Queenie Law, PhD","CONTACT","3970 2974","qlaw@hkmu.edu.hk",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Dr Queenie Law Pui Sze","Associate Professor","100642395",false,"NCT07635121","Effectiveness of Low-Calorie MIND-HK Diet and Very Low-Calorie Diet on Glycemic Control and Cardiovascular Outcomes in Adults With Type 2 Diabetes: A 12-Week Randomized Controlled Trial","Inclusion Criteria:\n\n1. aged 40 to 70 years old;\n2. diagnosed with Type II DM; and\n3. Chinese ethnicity and able to speak and understand Cantonese.\n\nExclusion Criteria:\n\n1. patients on dialysis;\n2. Type I and Type II DM patients with insulin use;\n3. allergic to more than one type of food in the Low-calorie MIND-HK diet and very Low-calorie MIND- HK diet (e.g. nuts, berries, olive oil, or fish);\n4. Pregnant or Breastfeeding Women;\n5. Individuals with severe mental health conditions including severe depression, anxiety or other mental issues may struggle with the psychological demands of a very low calorie diet;\n6. People with low BMI less than 18.5;\n7. participation ni any dietary program within the past 3 months.","ALL","40 Years","70 Years",{"count":55,"type":56},180,"ESTIMATED","INTERVENTIONAL",[59],"NA","The objective of this project is to assess the effectiveness of a low-calorie and very low-calorie Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND-HK) diet in improving glycemic control and cardiovascular outcomes in adults with T2DM. A total of 180 participants aged 40 to 70, diagnosed with T2DM, will be recruited and randomized into three groups: intervention 1 following the low-calorie MIND-HK diet, intervention 2 following the very low-calorie diet, and an attention control group. The two intervention groups will attend four in-person nutrition counseling sessions (one per week, 60 minutes per session, followed by a 30-minute Q\\&A) at a community centre and will use KetoMetrics Breath Ketone System and dietary mobile app, to track diet and monitor daily ketone levels for early signs of ketosis that may lead to diabetic ketoacidosis (DKA). The attention control group will receive an equal amount of attention through four in-person infectious disease counseling sessions. The primary outcome will be HbA1c levels. Secondary outcomes include fasting blood glucose, lipid profile, blood pressure, body mass index, waist circumference, breath ketone, scores from the Summary Diabetes Self-Care Activities (SDSCA) Questionnaire, and MIND diet scores. This study will contribute to the growing body of evidence on dietary interventions for managing T2DM in adults.",[62],"Diabetes Mellitus Type 2",[64,9,65],"Very low-calorie MIND-HK diet","KetoMetrics Breath Ketone System","NOT_YET_RECRUITING","2026-06-17",{"date":69,"type":70},"2026-06-22","ACTUAL",{"date":72,"type":56},"2026-07-01",{"date":74,"type":56},"2029-01-31",{"name":5,"class":6}]