[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570032":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":59,"collaborators":62,"id":65,"slug":24,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":24,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":89,"overallStatus":46,"whyStopped":24,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Uppsala University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Nordic Diet","EXPERIMENTAL","Dietary advice and provided with some key food items of the healthy Nordic diet",[13],"Other: Healthy Nordic Diet",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual care","ACTIVE_COMPARATOR","Dietary advice according to standard clinical care at the cardiology unit",[19],"Behavioral: Usual Care",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"Participants will be adviced a healthy Nordic diet and will also receive certain Nordic foods high in wholegrains and polyunsaturated fat from vegetable sources",[9],null,{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":24},"BEHAVIORAL","Usual Care","Usual care lifestyle advice and national and general recommendations on diet",[15],[31],{"name":32,"affiliation":5,"role":33},"Ulf Risérus, MMED, PHD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Emil Hagström, MD, PHD","CONTACT","46184710000","emil.hagstrom@ucr.uu.se",{"name":41,"role":37,"phone":24,"phoneExt":24,"email":42},"Fredrik Rosqvist, PHD","fredrik.rosqvist@uu.se",[44],{"facility":45,"status":46,"city":47,"state":24,"zip":24,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Cardiology clinic, Uppsala university hospital","RECRUITING","Uppsala","Sweden","SE",{"type":51,"coordinates":52},"Point",[53,54],17.63889,59.85882,{"lat":54,"lon":53},[57],{"name":36,"role":37,"phone":58,"phoneExt":24,"email":39},"+46184710000",{"type":33,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Ulf Risérus","Professor",[63],{"name":64,"class":6},"Falu Hospital","100570032",false,"NCT06701968","Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease","A Healthy Nordic Diet to Reduce the Progression of Atherosclerosis in Individuals with Coronary Heart Disease: a Secondary Prevention Trial","NORDHEART","Inclusion Criteria:\n\n* Men and women\n* Diagnosis with MI from 2 weeks after diagnosis and with maximum 6 months after diagnosis\n* Diagnosis with CCS (e.g. stable angina pectoris)\n* Ages 50 to 80 years\n* BMI 25-40.\n\nExclusion Criteria:\n\n* Severe heart failure (NYHA classes III, IV)\n* Alcohol intake \\>20g\u002Fday\n* Unwillingness to follow a new prescribed diet for 18 months\n* Other diseases implying a short estimated life expectancy (e.g. severe malignant or kidney or liver disease, as judged by consenting physician).","ALL","50 Years","80 Years",{"count":76,"type":77},150,"ESTIMATED","INTERVENTIONAL",[80],"NA","Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear. The investigators will investigate if a healthy Nordic diet (HND) reduces plaque volume, coronary artery calcification (CAC), and plaque inflammation (FAI) in CHD, and examine if changes in gut microbiota may be linked to plaque progression over time. The investigators will also explore if the diet response can be predicted by the metabolic phenotype.\n\nIn total 150 CHD patients is randomized to a HND rich in unsaturated fat and fibre from plants, or to a \"usual care diet\" for 18 months. Plaque volume and composition is assessed by CT, and fecal microbiota composition is determined by deep metagenome shotgun sequencing. CHD and metabolic risk factors, liver fat, muscle fat and biomarkers of diet adherence (plasma fatty acids, whole-grain metabolites) are measured. Machine-learning is used to identify diet \"responders\" on plaque progression, based on the individual microbiome and metabolome.\n\nIf a HND reduces plaque progression, this would be novel information of clinical importance. Also, if the diet alters microbiota that are linked to plaque progression, this would be of high scientific interest. Finally, potential prediction of the diet-response would open up for more personalized treatment of atherosclerosis.",[83,84,85,86,87,88],"Coronary Disease","Coronary Arteriosclerosis","Myocardial Infarction","Chronic Coronary Syndrome","MASLD","Type 2 Diabetes",[90,91,92,93,94,95,96,97,98,99],"Diet","Secondary prevention","Coronary plaque regression","Atherosclerosis","Type 2 diabetes","Coronary heart disease","Myocardial infarction","Coronary computed tomography angiography","Healthy nordic diet","NAFLD","2025-03-05",{"date":102,"type":103},"2025-03-06","ACTUAL",{"date":105,"type":77},"2025-03-20",{"date":107,"type":77},"2031-12-30",{"name":5,"class":6},1]