[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610738":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":39,"responsibleParty":60,"collaborators":63,"id":66,"slug":24,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":24,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":24,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequence 1: Grape then Placebo","EXPERIMENTAL","Whole freeze-dried grape powder for 4 weeks, 4-week washout, then isocaloric placebo powder for 4 weeks.",[13,14],"Other: Freeze-dried grape powder","Other: Placebo powder",{"label":16,"type":10,"description":17,"interventionNames":18},"Sequence 2: Placebo then Grape","Isocaloric placebo powder for 4 weeks, 4-week washout, then whole freeze-dried grape powder for 4 weeks.",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Freeze-dried grape powder","48 g\u002Fday oral consumption during the 4-week active period.",[9,16],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Placebo powder","Isocaloric placebo matched to grape powder; oral consumption during the 4-week active period.",[9,16],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Jaapna Dhillon PhD, PhD","CONTACT","573-884-2103","jdhillon@health.missouri.edu",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Caitlyn Winn, MS","207-210-8049","cawq6x@umsystem.edu",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Columbia","Missouri","65211","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-92.33407,38.95171,{"lat":51,"lon":50},[54,55,58],{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},{"name":56,"role":57,"phone":24,"phoneExt":24,"email":24},"Jaapna Dhillon, PhD","PRINCIPAL_INVESTIGATOR",{"name":36,"role":59,"phone":24,"phoneExt":24,"email":24},"SUB_INVESTIGATOR",{"type":57,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Jaapna Dhillon","Assistant Professor",[64],{"name":65,"class":6},"California Table Grape Commission","100610738",false,"NCT07231484","Effects of Grape Consumption on the Immune-Gut Axis in Obesity","Effects of Grape Consumption on Immune and Gut Health in the Setting of Obesity","Inclusion Criteria:\n\n* Age: 30-45 years\n* Obesity with BMI of 30-45 kg\u002Fm2\n* Willingness to consume study foods\n* Consistent diet and activity patterns for 4 weeks\n* Weight stable (\\\u003C5kg change over last 3 months)\n* Non-smoker \\> 1 year or more\n* Not currently consuming an extremely healthy diet\n\nExclusion Criteria:\n\n* Study food allergies\n* Regular consumption of grapes or grape-derived products\n* Gastrointestinal disease and\u002For bariatric surgery\n* Uncontrolled hypertension and blood pressure \\>180\u002F110\n* Diabetes\n* Clinical Depression\n* Illicit drug use\n* History of alcohol or drug abuse\n* Recent use of medications that affect immune function (e.g., corticosteroids)\n* Recent consumption of antibiotics, prebiotics, probiotics, symbiotics, or dietary supplements containing fiber or phytochemicals\n* Pregnant or lactating individuals\n* HIV positivity\n* Recent start of medications that affect metabolism or appetite\n* Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia","ALL","30 Years","45 Years",{"count":76,"type":77},50,"ESTIMATED","INTERVENTIONAL",[80],"NA","This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.",[83],"Obesity &Amp; Overweight",[85,86,87,88,89,90],"Obesity","Immunity","Microbiome","Gut","Grape","Stress","2025-12-22",{"date":93,"type":94},"2025-12-30","ACTUAL",{"date":96,"type":94},"2025-12-19",{"date":98,"type":77},"2027-12-30",{"name":5,"class":6},1]