Effects of Oral Collagen Drinks on Human Skin
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorTCI Co., Ltd.
About this trial
The objective of this study is to evaluate the effect of oral collagen drink and MAXI collagen drink on human skin condition improvement.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy Chinese subjects aged 18 to 60 years, both male and female.
Wrinkle Severity: Crow's feet graded 2-4; under-eye fine lines graded 2-5; nasolabial folds graded 1-3.
Presence of facial skin laxity and sagging.
Ability to undergo skin examinations and pre-treatment in the designated test areas.
Disqualifiers
Pregnant or lactating women, or those planning to become pregnant in the near future.
Highly sensitive constitution, history of allergic diseases, or history of allergies to cosmetics.
Presence of skin diseases (e.g., psoriasis, eczema, atopic dermatitis, severe acne) or other chronic systemic diseases.
Skin conditions in the test area such as birthmarks, hyperpigmentation, inflammation, scars, nevi (moles), or hypertrichosis (excessive hair).
Trial design
Design model
Parallel
Treatments tested in this trial
Collagen Drink
Dietary supplementconsume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 5 g Collagen Powder
MAXI Collagen Drink
Dietary supplementconsume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 15 mL MAXI Collagen Liquid (equivalent to 5 g of deep hydrolyzed collagen net weight)
MAXI Collagen Drink_High dose
Dietary supplementconsume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 30 mL MAXI Collagen Liquid (equivalent to 10 g of deep hydrolyzed collagen net weight)
Treatment groups
99 Participants
are divided into 3 treatment groupsGroup A: Collagen DrinkActive comparator 1 intervention
Group B: MAXI Collagen DrinkExperimental treatment 1 intervention
Group C: MAXI Collagen Drink_High doseExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
The change of collagen fiber fluorescence intensity
SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to evaluate the density and quality of dermal collagen fibers.
Time frame
Change from Baseline collagen intensity at 4 weeksSecondary outcomes
1
The change of skin elasticity
Cutometer® MPA580 (CK, Germany) was utilized to measure the gross elasticity of the skin using suction method.
Time frame
Change from Baseline skin elasticity at 4 weeks2
The change of skin firmness
Cutometer® MPA580 (CK, Germany) was utilized to measure skin firmness and the area under the suction curve.
Time frame
Change from Baseline skin firmness at 4 weeks3
The change of epidermal thickness
SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to measure the depth of the epidermal layer using optical imaging.
Time frame
Change from Baseline epidermal thickness at 4 weeks4
The change of cheek skin roughness
AEVA-HE (EOTECH, France) was utilized to measure the arithmetic average roughness (Ra value) of the cheek surface.
Time frame
Change from Baseline skin roughness at 4 weeksOther outcomes
1
The change of skin brightness (L*)
Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin brightness (L\*).
Time frame
Change from Baseline skin brightness (L*) at 4 weeks2
The change of skin individual typology angle (ITA)
Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin individual typology angle (ITA).
Time frame
Change from Baseline skin ITA at 4 weeks3
The change of skin color parameters
Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin redness (a\*).
Time frame
Change from Baseline skin redness (a*) at 4 weeks4
The change of skin color parameters
Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin yellow tone (b\*).
Time frame
Change from Baseline skin yellow tone (b*) at 4 weeksSponsors and contacts
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Source ClinicalTrials.gov