[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521628":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":19,"locations":28,"responsibleParty":49,"collaborators":11,"id":51,"slug":11,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":11,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":11,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":31,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Integrative Skin Science and Research","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Skin Barrier Oral Supplement","EXPERIMENTAL",null,[13],"Dietary Supplement: Skin Barrier Oral Supplement",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":11},"DIETARY_SUPPLEMENT","Supplment powder",[9],[20,25],{"name":21,"role":22,"phone":23,"phoneExt":11,"email":24},"Caitlin Egli","CONTACT","916-750-2463","research@integrativeskinresearch.com",{"name":26,"role":22,"phone":11,"phoneExt":11,"email":27},"Milred Min","milred@integrativeskinresearch.com",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Integrative Skin and Research","RECRUITING","Sacramento","California","95815","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-121.4944,38.58157,{"lat":41,"lon":40},[44,46],{"name":45,"role":22,"phone":23,"phoneExt":11,"email":24},"Raja Sivamani, MD, MS, AP",{"name":47,"role":48,"phone":11,"phoneExt":11,"email":11},"Raja Sivamani, MD MS AP","PRINCIPAL_INVESTIGATOR",{"type":50,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100521628",false,"NCT06072066","Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea","The Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea","Inclusion Criteria:\n\n* Males and females 30 to 70 years of age\n* The presence of mild to moderate rosacea (erythematotelangiectatic or papulopustular)\n* High sensitivity C-reactive protein (hs-CRP) that is greater than or equal to 1.0 mg\u002FL\n\nExclusion Criteria:\n\n* The presence of severe rosacea as noted by the investigator global assessment.\n* Those who are unwilling to discontinue oral supplementation, or supplement ingredients found in the study's oral product 1 month prior to enrollment.\n* Discontinuation of oral L-glutamine or L-glutamine containing supplement 1 month prior to enrollment\n* Those who are unwilling to discontinue topical benzoyl peroxide or retinoids for 2 weeks prior to enrollment.\n* Those who are unwilling to keep their facial regimen the same throughout the study.\n* Individuals who have been on an oral antibiotic within the previous one month.\n* Individuals who are pregnant or breastfeeding.\n* Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study.\n* Individuals on oral contraceptive pills or progesterone or estrogen containing therapies.\n* Use of isotretinoin within the three months prior to enrollment.\n* Individuals on finasteride or dutasteride\n* Current tobacco smoker, smoker within the past year, or greater than 5 pack-year tobacco smoking history.",true,"ALL","30 Years","70 Years",{"count":62,"type":63},24,"ESTIMATED","INTERVENTIONAL",[66],"NA","The purpose of this study is to evaluate how supplementation will alter the skin and the gut barrier and inflammation in those with rosacea.",[69,70],"Rosacea","Systemic Inflammation",[69,72,73],"L-Histidine","Antioxidants","2024-08-26",{"date":76,"type":77},"2024-08-27","ACTUAL",{"date":79,"type":77},"2023-11-22",{"date":81,"type":63},"2024-12-31",{"name":5,"class":6},1]