[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638369":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":71,"locations":76,"responsibleParty":92,"collaborators":31,"id":94,"slug":31,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":95,"sex":101,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":31,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":78,"whyStopped":31,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"National Medical Research Center for Therapy and Preventive Medicine","OTHER_GOV",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1: Short Course IHHT (3 days)","EXPERIMENTAL","Participants receive 3 consecutive daily sessions of IHHT (24 minutes each, 3 cycles of 5-min hypoxia\u002F3-min hyperoxia, target SpO2 80-85%)",[13],"Other: Intermittent Hypoxic-Hyperoxic Training (3 days)",{"label":15,"type":10,"description":16,"interventionNames":17},"Arm 2: Long Course IHHT (10 days)","Participants receive 10 daily sessions of IHHT (40 minutes each, 5 cycles of 5-min hypoxia\u002F3-min hyperoxia, target SpO2 80-85%, excluding weekends and holidays)",[18],"Other: Intermittent Hypoxic-Hyperoxic Training (10 days)",{"label":20,"type":21,"description":22,"interventionNames":23},"Arm 3: Control","SHAM_COMPARATOR","Participants receive 10 daily sessions of breathing gas mixture with constant O2 21% for 40 minutes (excluding weekends and holidays)",[24],"Other: Normoxic gas breathing",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"OTHER","Intermittent Hypoxic-Hyperoxic Training (3 days)","Three daily sessions using HYPO-OXY-1 (OXYTERRA) device",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Intermittent Hypoxic-Hyperoxic Training (10 days)","Ten daily sessions using HYPO-OXY-1 (OXYTERRA) device",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Normoxic gas breathing","Ten daily sessions of breathing gas mixture with constant O2 21%",[20],[41,44,46,49,51,53,55,57,59,61,63,65,67,69],{"name":42,"affiliation":5,"role":43},"Marina I Smirnova, PhD","STUDY_CHAIR",{"name":45,"affiliation":5,"role":43},"Svetlana A Berns, MD, Prof.",{"name":47,"affiliation":5,"role":48},"Oksana M Drapkina, MD, Prof.","PRINCIPAL_INVESTIGATOR",{"name":50,"affiliation":5,"role":43},"Alexandr Yu Gorshkov, PhD",{"name":52,"affiliation":5,"role":43},"Mikhail G Chashchin, PhD",{"name":54,"affiliation":5,"role":43},"Liubov Lifanova, PhD",{"name":56,"affiliation":5,"role":43},"Andrey I Korolev, PhD",{"name":58,"affiliation":5,"role":43},"Diana N Antipushina, PhD",{"name":60,"affiliation":5,"role":43},"Lidia N Ryuzhakova, PhD",{"name":62,"affiliation":5,"role":43},"Elena N Ignatikova",{"name":64,"affiliation":5,"role":43},"Svetlava Voinova",{"name":66,"affiliation":5,"role":43},"Olga Zhdanova",{"name":68,"affiliation":5,"role":43},"Ailina M Zhulaushinova",{"name":70,"affiliation":5,"role":43},"Alexandr V Emelyanov",[72],{"name":52,"role":73,"phone":74,"phoneExt":31,"email":75},"CONTACT","+79774331118","dr.chaschin@gmail.com",[77],{"facility":5,"status":78,"city":79,"state":31,"zip":31,"country":80,"countryCode":81,"cosmosGeoPoint":82,"geoPoint":87,"contacts":88},"RECRUITING","Moscow","Russia","RU",{"type":83,"coordinates":84},"Point",[85,86],37.61781,55.75204,{"lat":86,"lon":85},[89],{"name":90,"role":73,"phone":91,"phoneExt":31,"email":31},"Oksana Drapkina","+7 (495) 212-07-13",{"type":93,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100638369",false,"NCT07574333","Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly","A Single-Center Randomized Clinical Trial With Prospective Follow-up of the Efficacy and Safety of Short and Long Duration Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Mellitus Including Elderly Patients","EFIR","Inclusion Criteria:\n\n* Age 50-74 years inclusive\n* Type 2 diabetes mellitus confirmed by medical documentation\n* Stable therapy for diabetes and other chronic diseases for at least 4 weeks prior to enrollment\n* Ability to comply with study protocol requirements\n* Signed informed consent\n\nExclusion Criteria:\n\n* Type 1 diabetes mellitus\n* Acute diabetes complications within 6 months (diabetic ketoacidosis, hyperosmolar hyperglycemic state, lactic acidosis, hypoglycemic coma)\n* Acute or active chronic infections\n* Angina pectoris functional class III-IV\n* Uncontrolled grade 3 arterial hypertension (SBP ≥180 and\u002For DBP ≥110 mmHg)\n* Acute cerebrovascular accident, myocardial infarction, surgical interventions, clinically significant injuries within 6 months\n* Internal carotid artery stenosis \\>60% and\u002For symptomatic stenosis 50-99%\n* Chronic obstructive pulmonary disease and bronchial asthma\n* Exacerbation and decompensation of chronic diseases within 1 month ALT and\u002For AST levels \\>2-3 times upper limit of normal\n* Congenital heart and major vessel abnormalities\n* Implanted cardiac pacemaker\n* Cancer with remission \\\u003C5 years\n* Mental illness, drug addiction, alcohol dependence\n* Pregnancy\n* Inability to participate throughout the study period","ALL","50 Years","74 Years",{"count":105,"type":106},250,"ESTIMATED","INTERVENTIONAL",[109],"NA","This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus aged 50-74 years. Participants will be randomized into three groups: 3-day IHHT course (n≥100), 10-day IHHT course (n≥100), or control group receiving gas mixture with constant O2 21% for 10 days (n≥50). The primary outcomes are fasting glucose levels and HbA1c. Secondary outcomes include cardiovascular parameters, quality of life, cognitive function, and biological age.",[112,113,114,115],"Type 2 Diabetes Mellitus (T2DM)","Hyperglycemia","Metabolic Syndrome","Older Adults (65 Years and Older)",[117,118,119,120,121,122,123],"Intermittent hypoxic-hyperoxic training","T2DM","Type 2 Diabetes Mellitus","Glycemic control","Elderly patients","Non-pharmacological intervention","Hypoxia conditioning","2026-05-04",{"date":126,"type":127},"2026-05-07","ACTUAL",{"date":129,"type":127},"2025-10-15",{"date":131,"type":106},"2027-12-15",{"name":5,"class":6},1]