About this trial
The aim of the study is to estimate the effectiveness of two different exercise programs combined with the Mediterranean diet versus diet alone on inflammatory status in subjects aged 18-65 years with obesity (BMI\>30) and Non-Alcoholic Fatty Liver Disease (NAFLD) (CAP \>248 dB/m).
Eligibility criteria
Qualifiers
BMI ≥ 30 kg/m2 or an abdominal circumference (waist) > 94 cm in men and > 80 cm in women (IDF criteria for the definition of abdominal obesity) with or without the characteristics that characterise metabolic syndrome
Age range 18-65 years, both sexes
Diagnosis of hepatic steatosis, formulated on the basis of recognised criteria (fibroscan (CAP (controlled attenuation parameter) > 238 dB/m)).
Disqualifiers
Normal and underweight subjects
Presence of any pathology that may influence the presence of steatosis apart from pathologies that are inclusion criteria, neurological and psychiatric pathologies, gastrointestinal, oncological and cardiovascular diseases
Pregnancy or breastfeeding
Subjects with osteoarticular pathologies that may prevent regular exercise
Trial design
Treatments tested in this trial
- Aerobic Exercise and diet intervention
- Hiit and diet intervention
- Diet
Treatment groups
Sponsors and collaborators
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Lead sponsor
Antonella Bianco
Collaborator
Isabella Franco
Collaborator