Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorSouthwest Hospital, China

About this trial

This is a multicenter, randomized, controlled clinical trial comparing neuroendoscopic hematoma removal to craniotomy in the treatment of large intracerebral hemorrhage.

Eligibility criteria

Qualifiers

Age 18-80 years old, male or female;

The time between onset and admission to the first diagnostic CT is within 24 hours (for no bystanders and the time of onset is unknown, the time of the last known patient in good condition is used);

Patients with supratentorial intracerebral hemorrhage (supratentorial intracerebral hemorrhage (supratentorial intracerebral hemorrhage) whose hematoma volume is ≥50ml or whose hematoma produces obvious space occupying effect and requires emergency surgery (including patients with cerebral hernia signs such as retarding or dilatation of light reflex of one pupil);

Before randomization, GCS score was 5-14, NIHSS score was ≥6;

Disqualifiers

The clinical diagnosis is caused by cerebral aneurysm, cerebrovascular malformation, moyamoya disease, brain trauma, brain tumor, massive cerebral infarction hemorrhage transformation, coagulation dysfunction, etc.;

Thalamic hemorrhage, primary ventricular hemorrhage;

Platelet count <100×109/L, INR > 1.4;

Patients with advanced cerebral hernia (such as dilated bifidus and no light reflex) or unstable vital signs cannot tolerate surgery;

Trial design

Treatments tested in this trial

  • neuroendoscopic surgery
  • craniotomy

Treatment groups

280 Participants
are divided into 2 treatment groups

Sponsors and collaborators