[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549941":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":36,"locations":10,"responsibleParty":45,"collaborators":10,"id":49,"slug":10,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":66,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I",null,"Age and sex matched healthy Control",[13],"Diagnostic Test: PCR",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2","50 patients with β-thalassemia major",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group 3","50 patients with β-thalassemia intermedia",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","PCR","Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) for detection of EKLF:\n\n* The method of total RNA extraction: TRIZOL and TRIZOL LS.\n* The purity and concentration of the RNA will be measured using Nano Drop 2000 instument.\n* cDNA will be done with primers using thr Goscript Reverse Transcription System",[15,19,9],[29,32,34],{"name":30,"affiliation":5,"role":31},"Eman Naser Eldin","STUDY_DIRECTOR",{"name":33,"affiliation":5,"role":31},"Sherif Helmy",{"name":35,"affiliation":5,"role":31},"Reem Elagoz",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Rofida Hassan","CONTACT","+2 1019935111","mahaseb_rofaida@yahoo.com",{"name":30,"role":39,"phone":43,"phoneExt":10,"email":44},"01002677890","emannasr2000@yahoo.com",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Rofaida Hassan Ahmed","Principle investigator","100549941",false,"NCT06440603","EKLF Gene Expression in β-thalassemia","Erythroid Krüppel Like Factor (EKLF) Gene Expression in β-thalassemia Patients","Inclusion Criteria:\n\n* patients with β-thalassemia (major and intermedia).\n* patients are of both sexes (male or female) at any age\n\nExclusion Criteria:\n\n* patients with any other types of hemolytic anaemia",true,"ALL","5 Years","80 Years",{"count":60,"type":61},150,"ESTIMATED","OBSERVATIONAL","1. Studying the effect of expression pattern of EKLF gene in β-thalassemic patients.\n2. Detecting the correlation between the gene expression of EKLF and the clinical phenotype of β-thalassemic patients.",[65],"β-thalassemia","NOT_YET_RECRUITING","2024-05-31",{"date":69,"type":70},"2024-06-04","ACTUAL",{"date":72,"type":61},"2024-07-01",{"date":74,"type":61},"2027-07-01",{"name":47,"class":6}]