[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624051":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":47,"collaborators":20,"id":49,"slug":20,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":20,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":20,"enrollmentInfo":57,"targetDuration":20,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":32,"whyStopped":20,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Institute of Oncology Ljubljana","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Electrochemotherapy (ECT)","EXPERIMENTAL","Patients with cutaneous melanoma with cutaneous and\u002For subcutaneous metastases undergoing electrochemotherapy as part of clinical management. Electrochemotherapy is performed using intravenous bleomycin or intratumoral cisplatin. Tumor samples are collected before and after treatment for analysis of tumor microenvironment changes.",[13],"Procedure: Electrochemotherapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Electrochemotherapy","Electrochemotherapy is performed according to standard clinical procedures with application of electric pulses combined with administration of cytotoxic agents (intravenous bleomycin or intratumoral cisplatin) for treatment of cutaneous and subcutaneous melanoma metastases.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Klavdija Korošec","CONTACT","+386 31630065","kkorosec@onko-i.si",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Neža Gros","ngros@onko-i.si",[31],{"facility":5,"status":32,"city":33,"state":20,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Ljubljana","1000","Slovenia","SI",{"type":38,"coordinates":39},"Point",[40,41],14.50513,46.05108,{"lat":41,"lon":40},[44,46],{"name":45,"role":24,"phone":25,"phoneExt":20,"email":26},"Korošec",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},{"type":48,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100624051",false,"NCT07404605","Electrochemotherapy-Induced Changes in Tumor Microenvironment in Cutaneous Melanoma","Electrochemotherapy Induces Changes in Tumor Microenvironment of Cutaneous and Subcutaneous Metastases in Patients With Cutaneous Melanoma","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Histologically confirmed cutaneous melanoma\n* Presence of cutaneous and\u002For subcutaneous metastases eligible for electrochemotherapy\n* Candidate for electrochemotherapy with intravenous bleomycin or intratumoral cisplatin according to standard clinical practice\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Contraindication to electrochemotherapy or study drugs (bleomycin or cisplatin)\n* Pregnancy or breastfeeding\n* Severe comorbidities preventing electrochemotherapy\n* Inability to comply with study procedures","ALL","18 Years",{"count":58,"type":59},150,"ESTIMATED","INTERVENTIONAL",[62],"NA","Cutaneous melanoma frequently develops cutaneous and subcutaneous metastases, which may cause significant morbidity and negatively affect quality of life. Electrochemotherapy (ECT) is an established local treatment modality for cutaneous and subcutaneous tumor lesions that combines the administration of cytotoxic drugs with the application of electric pulses to increase drug uptake into tumor cells.\n\nIn addition to its direct cytotoxic effects, electrochemotherapy may induce changes in the tumor microenvironment, including immune cell infiltration, vascular alterations, and other biological responses that could influence tumor control.\n\nThe aim of this study is to evaluate changes in the tumor microenvironment of cutaneous and subcutaneous melanoma metastases following electrochemotherapy with either intravenous bleomycin or intratumoral cisplatin. Tumor tissue samples collected before and after treatment will be analyzed to characterize microenvironmental changes and to compare treated and untreated lesions.\n\nThe results of this study may improve understanding of biological effects of electrochemotherapy in melanoma metastases and support further development of treatment strategies.",[65,66],"MELANOMA","SKIN NEOPLASMS",[65],"2026-02-17",{"date":70,"type":71},"2026-02-19","ACTUAL",{"date":73,"type":71},"2023-09-01",{"date":75,"type":59},"2026-09-30",{"name":5,"class":6},1]