[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608475":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":30,"locations":36,"responsibleParty":56,"collaborators":61,"id":65,"slug":29,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":29,"enrollmentInfo":73,"targetDuration":29,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":39,"whyStopped":29,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Prisma Health-Upstate","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Sweet-Cooling EC + Counseling","EXPERIMENTAL","Those randomized to the intervention group will be provided a free 12-week supply of sweet-cooling electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.",[13],"Behavioral: Brief individual counseling sessions",{"label":15,"type":10,"description":16,"interventionNames":17},"Sweet non-cooling EC + Counseling","Those randomized to the intervention group will be provided a free 12-week supply of sweet non-cooling electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Tobacco-flavored EC + Counseling","ACTIVE_COMPARATOR","Those randomized to the intervention group will be provided a free 12-week supply of tobacco-flavored electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"BEHAVIORAL","Brief individual counseling sessions","Five brief, individual counseling sessions will provide education, behavioral support, and motivational strategies to facilitate switching from combustible cigarette use to EC",[15,9,19],null,[31],{"name":32,"role":33,"phone":34,"phoneExt":29,"email":35},"Irene Pericot-Valverde, PhD","CONTACT","(864)656-4467","iperico@clemson.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Addiction Medicine Center","RECRUITING","Greenville","South Carolina","29605","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-82.39401,34.85262,{"lat":49,"lon":48},[52],{"name":53,"role":33,"phone":54,"phoneExt":29,"email":55},"Alain Litwin, MD","864-455-5648","alain.litwin@prismahealth.org",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":60,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Irene Pericot-Valverde","Assistant Professor","Clemson University",[62],{"name":63,"class":64},"National Institute on Drug Abuse (NIDA)","NIH","100608475",false,"NCT07202039","Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine","SWITCH","Inclusion Criteria\n\n* Age ≥21 years\n* Smoke ≥5 CPD for ≥1 year\n* Daily CC smoker\n* Willing to switch to EC\n* Exhaled CO ≥6 ppm\n* Diagnosed with OUD\n* Stable on bupropion treatment\n* In good physical and mental health\n* Able to use a smartphone\n* Willing to participate in all study components\n* Able to provide informed consent Exclusion Criteria\n* Interested in quitting CC (contemplation stage of change)\n* Use of EC on ≥4 of the past 30 days\n* Use of other tobacco products (e.g., cigars, smokeless tobacco) on ≥9 days of the past 30 days\n* Use of nicotine replacement therapy, smoking cessation medication, or a cessation attempt in the past 30 days\n* Hypertension\n* Medical condition that would contraindicate participation\n* Meet DSM-V criteria for major depressive episode, psychotic episode, or manic episode\n* Current suicidal ideation or suicide attempt in the past year\n* Psychiatric hospitalization in the past year\n* Contemplating pregnancy, currently pregnant, or breastfeeding\n* Unable to speak and\u002For read English","ALL","21 Years",{"count":74,"type":75},90,"ESTIMATED","INTERVENTIONAL",[78],"NA","This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking buprenorphine",[81,82,83],"Tobacco-flavored EC","Sweet-Cooling EC","Sweet Non-cooling EC",[85,86,87,88,89,90],"Cigarette Smoking","Opioid use disorder","Burprenorphine","Electronic cigarettes","Switching","Flavors","2026-05-11",{"date":93,"type":94},"2026-05-12","ACTUAL",{"date":96,"type":94},"2026-04-29",{"date":98,"type":75},"2029-06-29",{"name":5,"class":6},1]