[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100054009":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":54,"centralContacts":58,"locations":64,"responsibleParty":82,"collaborators":10,"id":85,"slug":10,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":10,"studyType":99,"phases":10,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":66,"whyStopped":10,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"migraine",null,"patients with migraine",[13,14,15,16,17],"Device: Thermal stimuli","Device: Pressure stimuli","Behavioral: Pain ratings","Behavioral: Conditioned pain modulation (CPM) response","Biological: Hormonal assessment",{"label":19,"type":10,"description":20,"interventionNames":21},"Endometriosis","patients with endometriosis",[13,14,15,16,17],{"label":23,"type":10,"description":24,"interventionNames":25},"migraine and endometriosis","patients with migraine and endometriosis",[13,14,15,16,17],{"label":27,"type":10,"description":28,"interventionNames":29},"control","healthy participants with no migraine or endometriosis",[13,14,15,16,17],[31,36,40,45,49],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":10},"DEVICE","Thermal stimuli","The Thermal Sensory Analyzer (TSA-II or PATHWAY platform - Medoc, Ramat Yishai, Israel) will be used to safely deliver heat and cold stimuli. These devices can deliver relatively complex stimuli via computer control. All targeted stimulus temperatures will be less than 50°C, and participants will be free to remove their arm or leg at any time from the thermode. Noxious cold stimuli will also be delivered with a plastic water container or a water bath (FISHER, USA). Participants will be free to pull out of the water bath at any time",[19,27,9,23],{"type":32,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"Pressure stimuli","Pressure stimuli will be applied by using a handheld algometer (Wagner Instruments) or the Pressure Algometer (Medoc, Ramat Yishai, Israel). These devices have a round probe that allows quantifying the amount of pressure that is being applied. The Pressure Algometer allows a real-time visual feedback to control and monitor applied pressure rates. Pressure will be applied to the lower leg, volar forearm, or trapezius.",[19,27,9,23],{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":10},"BEHAVIORAL","Pain ratings","Pain intensity and pain unpleasantness ratings will be assessed.",[19,27,9,23],{"type":41,"name":46,"description":47,"armGroupLabels":48,"otherNames":10},"Conditioned pain modulation (CPM) response","The CPM paradigm assesses endogenous inhibitory pain modulation efficiency. CPM testing includes the application of a \"test\" stimulus without conditioning (control run, pressure pain thresholds) and a subsequent application of the same test stimulus together with a conditioning stimulus (conditioning run, a 60 second of foot immersion in cold water). The CPM response is the difference in the pressure pain thresholds between the control and the conditioning runs.",[19,27,9,23],{"type":50,"name":51,"description":52,"armGroupLabels":53,"otherNames":10},"BIOLOGICAL","Hormonal assessment","Blood samples (approximately 2 tablespoons) and\u002For saliva and\u002For urine will be collected for analyses of sex hormone levels (e.g., prolactin, testosterone, estradiol).",[19,27,9,23],[55],{"name":56,"affiliation":5,"role":57},"Hadas Nahman-Averbuch, PhD","PRINCIPAL_INVESTIGATOR",[59],{"name":60,"role":61,"phone":62,"phoneExt":10,"email":63},"Alana McMichael, MA","CONTACT","314-273-6194","painlab@wustl.edu",[65],{"facility":5,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"RECRUITING","St Louis","Missouri","63110","United States","US",{"type":73,"coordinates":74},"Point",[75,76],-90.19789,38.62727,{"lat":76,"lon":75},[79,81],{"name":80,"role":61,"phone":62,"phoneExt":10,"email":63},"Alana McMichael",{"name":56,"role":57,"phone":10,"phoneExt":10,"email":10},{"type":57,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Hadas Nahman-Averbuch","Assistant professor","100054009",false,"NCT06785129","Endometriosis and Migraine","Mechanisms Underlying Endometriosis and Migraine Comorbidity","EMC","Inclusion Criteria:\n\n1. Patients with diagnosed endometriosis, migraine, or both endometriosis and migraine\n2. Healthy control subjects with no history of chronic pain\n3. Age 12-45\n4. Assigned female sex at birth\n\nExclusion Criteria:\n\n1. Pregnancy or breastfeeding\n2. Presence of prolactinoma\n3. Presence of psychiatric, neurological, endocrinological and\u002For developmental conditions and taking medications for these conditions\n4. Current use of dopamine agonist or SSRI medications\n5. For patients aged 12-17 not having a parent\u002Flegal guardian willing to sign the consent and answer surveys about their child's health",true,"FEMALE","12 Years","45 Years",{"count":97,"type":98},120,"ESTIMATED","OBSERVATIONAL","This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples for hormone analyses.",[102,19],"Migraine",[102,104,105,106],"endometriosis","hormones","pain","2026-07-10",{"date":109,"type":110},"2026-07-13","ACTUAL",{"date":112,"type":110},"2025-02-12",{"date":114,"type":98},"2030-01-01",{"name":5,"class":6},1]