[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631992":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":32,"responsibleParty":49,"collaborators":20,"id":51,"slug":20,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":20,"enrollmentInfo":60,"targetDuration":20,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":35,"whyStopped":20,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Fondazione del Piemonte per l'Oncologia","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single-Arm Endoscopic Nipple-Sparing Mastectomy","EXPERIMENTAL","Eligible participants with breast cancer or ductal carcinoma in situ will undergo endoscopic nipple-sparing mastectomy through a single axillary incision, with immediate direct-to-implant breast reconstruction",[13],"Procedure: Endoscopic Nipple-Sparing Mastectomy (E-NSM)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Endoscopic Nipple-Sparing Mastectomy (E-NSM)","Endoscopic nipple-sparing mastectomy performed through a single extra-mammary axillary incision using a standardized minimally invasive surgical technique; immediate direct-to-implant reconstruction will be performed according to institutional practice.",[9],null,[22,28],{"name":23,"role":24,"phone":25,"phoneExt":26,"email":27},"Antonio Toesca, MD","CONTACT","0119933628","+39","antonio.toesca@ircc.it",{"name":29,"role":24,"phone":30,"phoneExt":26,"email":31},"Giada Pozzi, MD","0119933676","giada.pozzi@ircc.it",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Breast Unit","RECRUITING","Candiolo","Turin","10060","Italy","IT",{"type":42,"coordinates":43},"Point",[44,45],7.59812,44.95858,{"lat":45,"lon":44},[48],{"name":23,"role":24,"phone":25,"phoneExt":26,"email":27},{"type":50,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100631992",false,"NCT07507890","Endoscopic Nipple-Sparing Mastectomy Through a Single Axillary Incision in Breast Cancer","MINI-B - Minimally Invasive Endoscopic Mastectomy Using a Single Axillary Incision in Breast Cancer Patients: a Prospective Cohort Study","Mini-B","Inclusion Criteria:\n\n* Female participants aged 18 years or older.\n* Diagnosis of early-stage invasive breast cancer or ductal carcinoma in situ, including multifocal or multicentric disease.\n* Candidate for nipple-sparing mastectomy with immediate direct-to-implant reconstruction.\n* Small- to medium-sized breasts with ptosis grade 2 or less.\n* Written informed consent provided.\n\nExclusion Criteria:\n\n* Preoperative evidence of skin involvement, nipple-areola complex involvement, lymph-node metastases, inflammatory breast cancer, Paget's disease, mesenchymal breast tumors, or recurrent breast cancer.\n* Previous ipsilateral breast surgery.\n* Previous thoracic radiation therapy.\n* Heavy smoking (\\>20 cigarettes\u002Fday), uncontrolled diabetes mellitus, or body mass index \\>30.\n* ASA score 3 or higher.\n* Ongoing pregnancy","FEMALE","18 Years",{"count":61,"type":62},10,"ESTIMATED","INTERVENTIONAL",[65],"NA","This single-center prospective study will evaluate the feasibility and safety of endoscopic nipple-sparing mastectomy (E-NSM) performed through a single axillary incision in selected women with breast cancer undergoing direct-to-implant breast reconstruction. The study will assess procedural feasibility, completeness of resection, short-term postoperative complications, and patient-reported outcomes",[68,69],"Breast Cancer - Ductal Carcinoma in Situ (DCIS)","Breast Cancer",[71,72,73,74],"Breast","Endoscopic Nipple-Sparing","Mastectomy","E-NSM","2026-03-30",{"date":77,"type":78},"2026-04-02","ACTUAL",{"date":80,"type":78},"2025-06-11",{"date":82,"type":62},"2026-12-30",{"name":5,"class":6},1]