Ethanol Consumption in the Heat

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19+
SponsorLakehead University

About this trial

Climate change has significantly increased the earth's average surface temperature and heat waves have been predicted to increase in frequency, intensity and duration. Extreme heat events have increased the susceptibility to heat-related illnesses, such as heat exhaustion, heat stroke or death. Heat health action plans have been designed to advertise cooling behaviours to mitigate physiological strain. Heat health action plans suggest avoiding alcohol consumption during extreme heat as it may increase dehydration and impair behavioural or physiological temperature regulation and thermal perception. Regardless of these messages, alcohol sales continue to remain high during the summer months year after year, and 1/5 of adults identify alcohol as a hydration strategy during extreme heat events. A recent scoping review investigating the effects of alcohol and heat has demonstrated that acute alcohol consumption does not negatively influence thermoregulation, hydration, or hormone markers of fluid balance in the heat compared to a control fluid (https://doi.org/10.1186/s12940-024-01113-y). Further, alcohol consumption may elicit sex- and age-specific alterations in physiological and perceptual responses, neither of which have been explored.

Therefore, this study aims to comprehensively evaluate how alcohol consumption systematically alters physiological responses and perceptions during conditions similar to those experienced indoors during extreme heat events in younger and older adults.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Male or Female above the age of 19

Able to provide informed consent

Disqualifiers

History of cardiovascular disease, cancer, type 1 or 2 diabetes, chronic obstructive pulmonary disorder, cystic fibrosis, or alcohol addiction or dependence

Been hospitalized due to COVID-19

Pregnant/Breastfeeding

Scoring an eight or above on the Alcohol Use Disorders Identification Test (AUDIT)

Trial design

Design model

Crossover

Treatments tested in this trial

  • Placebo Beverage

    Drug

    Participants rest in a climate controlled room maintained at 40°C and 30%RH for 120 minutes follow placebo beverage consumption (180 minutes total).

  • Alcohol (Ethanol)

    Drug

    Participants rest in a climate controlled room maintained at 40°C and 30%RH for 120 minutes follow alcoholic beverage consumption (180 minutes total).

Treatment groups

34 Participants
are divided into 2 treatment groups
Group A: PlaceboPlacebo comparator 1 intervention
Group B: AlcoholActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Heart Rate

3-lead electrocardiogram

Time frame
measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
2

Skin Temperature

Mean skin (4 sites)

Time frame
measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
3

Core Temperature

measured rectally

Time frame
measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
4

Blood Pressure

ECG-gated blood pressure cuff

Time frame
measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

Secondary outcomes

1

Subjective Blood Alcohol Concentration (visual analog scale 0.0 - 0.20)

Visual analog scale with left and right anchors of 0.0 and 0.20, respectively, with markers every 0.005 increment

Time frame
measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
2

Blood Alcohol Concentration

Measured using a police grade portable breathalyzer

Time frame
measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

Other outcomes

Sponsors and contacts

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