This clinical study aims to assess feasibility, safety, tolerability, and compliance of a Nonessential Amino Acid Restriction (NEAAR) medical food in adult patients with locally advanced rectal cancer during standard of care short course radiotherapy followed by standard of care chemotherapy.
Histologically confirmed diagnosis of adenocarcinoma of the rectum
Clinical stage II (cT3-4, N-) or Stage III (cT any, N+) based on MRI
Eligible for total mesorectal excision
No evidence of distant metastasis
Patients unable to undergo MRI
Other anticancer or experimental therapy
Body mass index (BMI) <18.5 kg/m2 or >40 kg/m2
Serious or refractive cachexia or anorexia