Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorDuke University

About this trial

This prospective observational study aims to evaluate the incidence of hemidiaphragmatic paralysis in patients receiving interscalene brachial plexus nerve block with prolonged neural blockade. English speaking American Society of Anesthesiologists (ASA) 1-3 patients ages 18-80 receiving prolonged interscalene nerve block will be randomized into 3 groups: first group receiving a perineural catheter infusing 0.2% ropivacaine; the second group receiving a single shot injection of 10mL liposomal bupivacaine (Exparel; n=20) plus 5 mL 0.5% bupivacaine and the third receiving 20mL liposomal bupivacaine plus 5mL bupivacaine (to be determined by the attending anesthesiologist).Primary outcome will be incidence of hemidiaphragmatic paralysis postoperative day 1 as measured by point of care (POCUS) ultrasound.

Eligibility criteria

Qualifiers

English speaking 18-80 year old ASA 1-3 patients

Primary shoulder surgery

Must live within a 25 mile radius

Disqualifiers

ASA 4 or 5

Revision shoulder surgery

Diagnosis of chronic pain

Daily chronic opioid use (over 3 months of continuous opioid use)

Trial design

Treatments tested in this trial

  • Ultrasound
  • Ropivacaine
  • Bupivacaine
  • MediPines AGM100 Advanced Respiratory Monitoring System

Treatment groups

60 Participants
are divided into 3 treatment groups

Sponsors and collaborators