[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588553":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":20,"locations":20,"responsibleParty":21,"collaborators":20,"id":23,"slug":20,"hasResults":24,"nctId":25,"briefTitle":26,"officialTitle":27,"acronym":20,"eligibilityCriteria":28,"healthyVolunteers":29,"sex":30,"minAge":31,"maxAge":32,"enrollmentInfo":33,"targetDuration":20,"studyType":36,"phases":37,"briefSummary":39,"conditions":40,"keywords":20,"overallStatus":44,"whyStopped":20,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":20},{"fullName":5,"class":6},"Azienda di Servizi alla Persona di Pavia","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Melissa Officinalis Supplement","EXPERIMENTAL","Participants will receive a dietary supplement containing 400 mg of Melissa officinalis formulated in phospholipids once daily for 3 weeks.",[13],"Dietary Supplement: Melissa officinalis supplement",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIETARY_SUPPLEMENT","Melissa officinalis supplement","This intervention consists of a standardized oral dietary supplement containing 400 mg of Melissa officinalis extract formulated in phospholipids. The supplement is administered once daily for 3 weeks to evaluate its potential effects on mood, stress perception, and cortisol levels in healthy adults.",[9],null,{"type":22,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100588553",false,"NCT06942897","Evaluation of a Dietary Supplement Containing Melissa Officinalis Formulated in Phospholipids on Mood Well-being and Cortisol Modulation","Pilot Study for the Evaluation of a Dietary Supplement Containing Melissa Officinalis Formulated in Phospholipids on Mood Well-being and Cortisol Modulation","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Healthy volunteers as assessed by medical history and physical examination\n* Willingness to comply with the study procedures\n\nExclusion Criteria:\n\n* Current use of medications or supplements that may affect mood or cortisol levels\n* Known allergy or sensitivity to Melissa officinalis or phospholipids\n* History of psychiatric disorders (e.g., major depression, anxiety disorders)\n* Significant comorbidities (e.g., cardiovascular, hepatic, renal diseases)\n* Pregnant or breastfeeding women\n* Participation in another clinical trial in the past 30 days",true,"ALL","18 Years","65 Years",{"count":34,"type":35},40,"ESTIMATED","INTERVENTIONAL",[38],"NA","This is a randomized, double-blind, placebo-controlled pilot study designed to evaluate the effect of an oral nutritional supplement containing Melissa officinalis formulated in phospholipids on mood and cortisol levels in healthy adults. Participants will be randomly assigned to receive either the active supplement or a placebo daily for 3 weeks. The primary outcome measures include changes in mood well-being, perceived stress, and salivary cortisol levels. The study aims to assess both efficacy and safety of the supplement in modulating stress response and emotional balance.",[41,42,43],"Stress","Mood Disorders","Emotional Well-being","NOT_YET_RECRUITING","2025-11-23",{"date":47,"type":48},"2025-11-25","ACTUAL",{"date":50,"type":35},"2026-06-15",{"date":52,"type":35},"2026-09-15",{"name":5,"class":6}]