[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643167":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":25,"centralContacts":36,"locations":43,"responsibleParty":70,"collaborators":10,"id":73,"slug":10,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":10,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":94,"overallStatus":103,"whyStopped":10,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Toros University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"LSG Group",null,"Adults aged 19-50 years who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital. Participants will be evaluated at baseline and 6 months after surgery for metabolic parameters, intestinal permeability markers, gastrointestinal symptoms, anthropometric measurements, and dietary intake.",[13],"Other: Clinical and Biochemical Assessment",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Clinical and Biochemical Assessment","Participants will undergo two assessment visits: at baseline (within 1 month post-surgery) and at 6-month follow-up. Each visit includes anthropometric measurements (body weight, height, waist and hip circumference, BMI), biochemical blood analysis (fasting glucose, lipid profile, insulin, zonulin, secretory IgA, LPS), gastrointestinal symptom evaluation via GSRS, and 3-day dietary records.",[9],[20,21,22,23,24],"Anthropometric Measurement","Biochemical Blood Analysis","Gastrointestinal Symptom Rating Scale (GSRS)","3-Day Dietary Record","Intestinal Permeability Assessment",[26,29,32],{"name":27,"affiliation":5,"role":28},"Betül GÜLŞEN, Assoc. Prof.","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":5,"role":31},"Özlem ÖZPAK AKKUŞ, Assoc. Prof.","STUDY_CHAIR",{"name":33,"affiliation":34,"role":35},"Doğukan DURAK, Assoc. Prof.","Bursa Yıldırım Doruk Hospital, General Surgery Clinic","STUDY_DIRECTOR",[37,41],{"name":27,"role":38,"phone":39,"phoneExt":10,"email":40},"CONTACT","+903246253300","betul.atalay@toros.edu.tr",{"name":30,"role":38,"phone":39,"phoneExt":10,"email":42},"dytozlemozpak@hotmail.com",[44],{"facility":45,"status":10,"city":46,"state":46,"zip":47,"country":48,"countryCode":10,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Bursa Yıldırım Doruk Hospital","Bursa","16310","Turkey (Türkiye)",{"type":50,"coordinates":51},"Point",[52,53],29.06013,40.19559,{"lat":53,"lon":52},[56,60,61,64,65,66,68],{"name":57,"role":38,"phone":58,"phoneExt":10,"email":59},"Doğukan DURAK;, Assoc. Prof.","+905327243733","dogukandurak404@hotmail.com",{"name":27,"role":38,"phone":39,"phoneExt":10,"email":40},{"name":62,"role":63,"phone":10,"phoneExt":10,"email":10},"Doğukan Durak, Assoc. Prof.","SUB_INVESTIGATOR",{"name":27,"role":28,"phone":10,"phoneExt":10,"email":10},{"name":30,"role":28,"phone":10,"phoneExt":10,"email":10},{"name":67,"role":63,"phone":10,"phoneExt":10,"email":10},"Seher ŞEN, Asst. Prof.",{"name":69,"role":63,"phone":10,"phoneExt":10,"email":10},"Tuğçe Nur Doganay Yıldırım, MSc, RD",{"type":28,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Betül Gülşen","Assoc. Prof.","100643167",false,"NCT07643376","Evaluation of Metabolic Parameters, Intestinal Permeability and Gastrointestinal Symptoms After Bariatric Surgery in Body Weight Management","Evaluation of Postoperative Metabolic Parameters, Intestinal Permeability and Gastrointestinal Symptoms in Body Weight Management After Laparoscopic Sleeve Gastrectomy","METABAR","Inclusion Criteria:\n\n* Underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last 1 month\n* Aged between 19-50 years\n* BMI ≥40 kg\u002Fm² or BMI ≥35 kg\u002Fm² with obesity-related comorbidities\n* Signed informed consent form\n* Non-smoker and non-alcohol dependent\n\nExclusion Criteria:\n\n* Did not undergo or is not planned to undergo LSG\n* Outside the age range of 19-50 years\n* Did not sign the informed consent form\n* BMI \\\u003C40 kg\u002Fm² or BMI \\\u003C35 kg\u002Fm² without obesity-related comorbidities\n* Smoker or alcohol dependent\n* Has an inflammatory disease\n* Currently using probiotics, antibiotics, or fiber supplements\n* Has a psychiatric disorder","ALL","19 Years","50 Years",{"count":84,"type":85},40,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the changes in metabolic parameters, intestinal permeability, and gastrointestinal symptoms in individuals who have undergone bariatric surgery (Laparoscopic Sleeve Gastrectomy - LSG) for obesity treatment.\n\nObesity is a chronic disease associated with serious health complications including type 2 diabetes, hypertension, cardiovascular disease, and metabolic disorders. Bariatric surgery is currently the most effective treatment method for morbid obesity. However, monitoring patients after surgery in terms of metabolic health, gut permeability, and gastrointestinal symptoms is crucial for long-term success.\n\nIn this study, 40 volunteers (aged 19-50) who have undergone LSG surgery within the last month will be followed for 6 months. At the beginning of the study and 6 months later, the following will be assessed:\n\n* Metabolic parameters: fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) cholesterol, and insulin levels\n* Intestinal permeability markers: zonulin, secretory immunoglobulin A (IgA), and lipopolysaccharide (LPS) levels\n* Gastrointestinal symptoms: assessed using the Gastrointestinal Symptom Rating Scale (GSRS)\n* Anthropometric measurements: body weight, height, waist and hip circumference, BMI\n* Nutritional intake: 3-day dietary records\n\nThe study will be conducted at Bursa Yıldırım Doruk Hospital, General Surgery Clinic. Results will contribute to understanding the relationship between bariatric surgery and gut health, potentially helping to prevent postoperative complications.",[89,90,91,92,93],"Obesity, Morbid","Bariatric Surgery","Intestinal Permeability","Gastrointestinal Symptoms","Metabolic Syndrome",[95,96,97,98,99,100,101,102],"Laparoscopic Sleeve Gastrectomy","Zonulin","Secretory IgA","Lipopolysaccharide","GSRS","Body Weight Management","Gut microbiota","Postoperative Metabolic Parameters","NOT_YET_RECRUITING","2026-06-08",{"date":106,"type":107},"2026-06-11","ACTUAL",{"date":109,"type":85},"2026-07-01",{"date":111,"type":85},"2027-02-01",{"name":5,"class":6},1]