Evaluation of Muscle Oxygen With MRI
ConditionMuscle Oxygenation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-64
SponsorIcahn School of Medicine at Mount Sinai
About this trial
Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Alert and oriented.
Able to lift 10lbs. and hold for 30 seconds
Not claustrophobic.
Intact sensation in right upper extremity.
Disqualifiers
Latex allergy or allergy to isopropyl alcohol.
Skin injury or decreased sensation on right upper extremity.
Trial design
Design model
Single group
Treatments tested in this trial
Compression and Contraction
Procedure/SurgeryStandard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a soft foam attached. Pressure will be applied intermittently with blood pressure cuff. Participant will also be asked to lift MRI compatible 10 lb. weight.
Treatment groups
75 Participants
are divided into 1 treatment groupGroup A: MRIExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Muscle oxygen level
Using functional MRI to evaluate effect of muscle compression on muscle oxygen. Demonstrating statistically significant change in muscle oxygen in tissues with application of tissue compression and muscle contraction compared to the same, non-compressed tissues with only muscle contraction
Time frame
Day 1, during procedureSecondary outcomes
1
Deep tissue oxygen level
Using functional MRI to evaluate the effect of muscle compression and contraction on deep tissue oxygen. Demonstrate statistically greater decreased tissue oxygenation in the deep soft tissues compared to the superficial tissues below the deforming element, during application of tissue compression, during muscle contraction as well during application of tissue compression and muscle contraction.
Time frame
Day 1, during procedureSponsors and contacts
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Source ClinicalTrials.gov