Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorUniversity of Kansas Medical Center
About this trial
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with muco-obstructive pulmonary disease. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
Eligibility criteria
Qualifiers
Adequate completion of informed consent process with written documentation
Patients 18 - 65 years old
• Physician diagnosis of muco-obstructive pulmonary disease, including cystic fibrosis, severe asthma, chronic obstructive pulmonary disease, or non-cystic fibrosis bronchiectasis for > 1 year
Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs.
Disqualifiers
Respiratory tract infection within the 4 weeks prior to Visit 1
Body mass index (BMI) > 30 at Visit 1
One-time doses such as intra-articular injections require a 4-week washout prior to Visit 1
ER visit related to pulmonary condition within the previous 4 weeks of Visit 1
Trial design
Treatments tested in this trial
- Hyperpolarized 129 Xenon
Treatment groups
8 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Kansas Medical Center
Lead sponsor
Polarean Imaging, Plc
Collaborator
Source ClinicalTrials.gov