[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100432839":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":53,"collaborators":25,"id":55,"slug":25,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":25,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Virginia Commonwealth University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Antioxidant then Placebo","EXPERIMENTAL","Subjects will ingest an antioxidant cocktail prior to their second visit and a placebo prior to third second visit",[13,14],"Dietary Supplement: Antioxidant","Dietary Supplement: Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Placebo then Antioxidant","Subjects will ingest a placebo prior to their second visit and an antioxidant cocktail prior to their third visit.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Antioxidant","Subjects will ingest an antioxidant cocktail containing 800 milligrams of alpha lipoic acid, 1 gram of vitamin C (ascorbic acid), and 400 milligrams of vitamin E (alpha tocopherol).",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo","Subjects will ingest placebo (microcrystalline cellulose) pills.",[9,16],[31],{"name":32,"affiliation":5,"role":33},"Ryan Garten, PhD","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","(804) 828-1948","rsgarten@vcu.edu",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":25},"RECRUITING","Richmond","Virginia","23298","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-77.46026,37.55376,{"lat":51,"lon":50},{"type":54,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100432839",false,"NCT04916327","Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1","Inclusion Criteria:\n\n* apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease\n* for PTSD group, a score of ≥ 33 on PCL-5 checklist\n* for GAD group, a score of ≥ 10 on the GAD-7 self-report scale and \\\u003C 33 on the PCL-5 checklist\n* for Healthy Control group, a score of ≤ 10 on the GAD-7 self-report scale and \\\u003C 33 on the PCL-5 checklist\n\nExclusion Criteria:\n\n* taking medications that could influence cardiovascular function\n* current smokers who have recently quit smoking\n* illicit drug use or excessive alcohol consumption\n* pregnant women\n* significant calorie restriction or vitamin\u002Fmineral deficiencies\n* limited English proficiency",true,"ALL","18 Years","35 Years",{"count":65,"type":66},720,"ESTIMATED","INTERVENTIONAL",[69],"NA","The purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and\u002For generalized anxiety disorder (GAD)).",[72],"Peripheral Vascular Diseases",[74,75,76,77,78],"cardiovascular disease","vascular function","PTSD","GAD","Oxidant","2026-06-29",{"date":81,"type":82},"2026-07-01","ACTUAL",{"date":84,"type":82},"2021-08-23",{"date":86,"type":66},"2026-08",{"name":5,"class":6},1]