[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525869":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":35,"locations":41,"responsibleParty":74,"collaborators":78,"id":84,"slug":25,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":25,"eligibilityCriteria":88,"healthyVolunteers":85,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":25,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Moderate Intensity Exercise","EXPERIMENTAL","Visit 1: Participants will complete study screening, PTSD assessments, and provide written narrative for a traumatic event and a neutral control event.\n\nVisit 2: Participants will complete baseline structural MRI scans before completing 8 trials of imaginal exposure - 4 neutral then 4 trauma narratives - with psychophysiological and fMRI measurement. Following completion of the imaginal exposure task, the participant will perform Moderate-Intensity Exercise (30-min at 70-75% max HR with 5-min warm-up and 5-min cool-down at 40-50% max HR), on a stationary bike.\n\nVisit 3: Participants will complete the same imaginal exposure with measurement of psychophysiology, fMRI, and subjective emotional responding.",[13],"Behavioral: Moderate Intensity Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Low Intensity Exercise","ACTIVE_COMPARATOR","Visit 1: Participants will complete study screening, PTSD assessments, and provide written narrative for a traumatic event and a neutral control event.\n\nVisit 2: Participants will complete baseline structural MRI scans before completing 8 trials of imaginal exposure - 4 neutral then 4 trauma narratives - with psychophysiological and fMRI measurement. Following completion of the imaginal exposure task, the participant will perform Low-Intensity Exercise (control; 40-mins at 40-50% max HR),on a stationary bike.\n\nVisit 3: Participants will complete the same imaginal exposure with measurement of psychophysiology, fMRI, and subjective emotional responding.",[19],"Behavioral: Low Intensity Exercise",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Participants will wear a heartrate monitor and cycle on a stationary bike at a slow speed for 5 minutes, then slowly cycle on a stationary bike for 30 minutes, then cycle on the stationary bike at a slow speed for 5 minutes.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Participants will wear a heartrate monitor and cycle on a stationary bike at a slow speed for 40 minutes.",[15],[30,33],{"name":31,"affiliation":5,"role":32},"Thomas G Adams, Jr., PhD","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":5,"role":32},"Christal Badour, PhD",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Christal G Badour, PhD","CONTACT","859-323-3817","christal.badour@uky.edu",[42,59],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Lexington","Kentucky","40506","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-84.47772,37.98869,{"lat":53,"lon":52},[56],{"name":57,"role":38,"phone":25,"phoneExt":25,"email":58},"Thomas G Adams, PhD","tom.adams@uky.edu",{"facility":60,"status":43,"city":61,"state":62,"zip":63,"country":47,"countryCode":48,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"University of Texas","Austin","Texas","78712",{"type":50,"coordinates":65},[66,67],-97.74306,30.26715,{"lat":67,"lon":66},[70],{"name":71,"role":38,"phone":72,"phoneExt":25,"email":73},"Josh Cisler, PhD","512-495-5162","josh.cisler@austin.utexas",{"type":75,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Christal L Badour","Associate Professor",[79,81],{"name":80,"class":6},"University of Texas at Austin",{"name":82,"class":83},"National Institute of Mental Health (NIMH)","NIH","100525869",false,"NCT06127342","Exercise and Emotional Learning in Posttraumatic Stress Disorder","Inclusion Criteria:\n\n* Adults with PTSD related to interpersonal violence\n\nExclusion Criteria:\n\n* Active or recent (within the last 3 months) severe substance use disorder(s)\n* Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms\u002F episodes\n* Significant developmental disabilities\n* Current daily benzodiazepine or stimulant use with inability to abstain for study sessions\n* Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks)\n* Medical condition(s) that prohibit exercise\n* History of traumatic brain injury (TBI) with loss of consciousness \\> 30 mins\n* Magnetic resonance imaging (MRI) contraindication(s)\n* Positive pregnancy test\n* History of seizure disorder\n* Spontaneous seizure(s) within the last 3 months","ALL","18 Years","64 Years",{"count":93,"type":94},100,"ESTIMATED","INTERVENTIONAL",[97],"NA","The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.",[100],"PTSD",[102,103],"Interpersonal Violence","Exercise","2025-08-26",{"date":106,"type":107},"2025-09-03","ACTUAL",{"date":109,"type":107},"2024-05-13",{"date":111,"type":94},"2026-11-30",{"name":76,"class":6},2]