[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613469":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":41,"locations":51,"responsibleParty":78,"collaborators":80,"id":83,"slug":36,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":36,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":104,"overallStatus":53,"whyStopped":36,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Medical University of Graz","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous Exercise","EXPERIMENTAL","Patients in this arm will undergo a 12-week training therapy regimen consisting of twice weekly supervised moderate-intensity continuous exercise (MICE) and home-based walking exercise for 30 minutes, five times a week, in addition.",[13],"Behavioral: Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"High Intensity Interval Exercise","Patients in this arm will undergo a 12-week training therapy regimen consisting of twice weekly supervised high-intensity interval exercise and home-based walking exercise for 30 minutes, five times a week, in addition.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Controls","ACTIVE_COMPARATOR","Patients in this arm will receive general recommendations on an active lifestyle, but will not take part in supervised training sessions and are not asked to do home-based exercise either.",[23],"Other: Control",[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","Exercise","1 study arm doing continuous type exercise will be compared to 1 study arm doing high-intensity interval exercise, over the course of 12 weeks, respectively. Both arms will be compared to sedentary control patients.",[9,15],[31],"Home-based walking exercise",{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Control","For patients in the control group, general exercise recommendations (e.g. recommendations by the CDC suitable for all adult individuals) will be given, however, no training therapy intervention is done and no home-based walking exercise is required either.",[19],null,[38],{"name":39,"affiliation":5,"role":40},"Elisabeth Taucher, Dr. Dr.","PRINCIPAL_INVESTIGATOR",[42,47],{"name":43,"role":44,"phone":45,"phoneExt":36,"email":46},"Lukas Spielbüchler, MEd, BEd","CONTACT","+43 699 10558825","lukas.spielbuechler@medunigraz.at",{"name":48,"role":44,"phone":49,"phoneExt":36,"email":50},"Emine Betül Deniz, MSc","+43 676 4029105","emine.deniz@medunigraz.at",[52],{"facility":5,"status":53,"city":54,"state":36,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"RECRUITING","Graz","8010","Austria","AT",{"type":59,"coordinates":60},"Point",[61,62],15.44197,47.06733,{"lat":62,"lon":61},[65,68,72,73,74,77],{"name":39,"role":44,"phone":66,"phoneExt":36,"email":67},"+43 6648438876","elisabeth.taucher@medunigraz.at",{"name":69,"role":44,"phone":70,"phoneExt":36,"email":71},"Nikolaus Kneidinger, Prof. Dr.","+43 316 385 12183","nikolaus.kneidinger@medunigraz.at",{"name":39,"role":40,"phone":36,"phoneExt":36,"email":36},{"name":69,"role":40,"phone":36,"phoneExt":36,"email":36},{"name":75,"role":76,"phone":36,"phoneExt":36,"email":36},"Lukas Spielbüchler, BEd, MEd","SUB_INVESTIGATOR",{"name":48,"role":76,"phone":36,"phoneExt":36,"email":36},{"type":79,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR",[81],{"name":82,"class":6},"Austrian Science Fund (FWF)","100613469",false,"NCT07267000","EXERCISE AND THE IMMUNE RESPONSE IN LUNG CANCER","ImmuEX","Inclusion Criteria:\n\n* Patients suffering from non-small cell or small-cell lung cancer of any histologic subtype, irrespective of routine treatment regimen\n* ECOG 0 or 1\n\nExclusion Criteria:\n\n* Kachexia (BMI\\\u003C18.5)\n* instable bone metastases\n* orthopedic condition rendering the patient unable to ride a stationary bike\n* any medical contraindication for exercise and training\n* a living will against basic or advanced life support","ALL","18 Years","75 Years",{"count":93,"type":94},50,"ESTIMATED","INTERVENTIONAL",[97],"NA","This project is about the effect of a 12-week training therapy intervention in patients suffering from non-small cell and small-cell lung cancer. It has widely been accepted that exercise is preventive against certain types of cancer. Individuals following an active lifestyle have a significantly lower risk for several chronic diseases, including cancer, as compared to sedentary ones. However, evidence is still lacking for exercise as part of routine cancer treatment. It has widely been accepted that exercise strongly impacts immune response, and might influence antitumor immune response as well. In this study, patients suffering from lung cancer undergo either a 12-week training program consisting of moderate-intensity continuous exercise (MICE), or a 12-week program with high-intensity interval exercise. Both groups will be compared to a control group receiving standard exercise recommendations. The immunologic response, i.e. cytokine profiles and changes in peripheral blood mononuclear cell (PBMC) characteristics will be the main endpoint. Blood will be taken from the patients at different timepoints, and blood samples will be tested for these immunologic changes. FACS analysis will be used to assess the properties of immune cells and potential changes upon the exercise regimen. Mitochondrial function will be assessed via the Seahorse machine, and mass spectrometry (lipidomics) will be used for the analysis of lipid profile changes.",[100,101,102,103],"Non-Small Cell Lung Cancer","Exercise Training","Immunotherapy","Small Cell Cancer Of The Lung",[105,27,102,106,107],"Non-small cell lung cancer","Outcome","Small-cell lung cancer","2026-06-08",{"date":110,"type":111},"2026-06-09","ACTUAL",{"date":113,"type":111},"2026-04-01",{"date":115,"type":94},"2029-05-01",{"name":5,"class":6},1]