[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498840":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":20,"responsibleParty":41,"collaborators":10,"id":43,"slug":10,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":10,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":10,"overallStatus":22,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"National Heart Centre Singapore","OTHER",[8,12,15,17],{"label":9,"type":10,"description":11,"interventionNames":10},"A",null,"1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography\n2. Bio-specimen collection\n3. Six-minute walk test\n4. Musculoskeletal Analysis\n5. Cardiopulmonary exercise test",{"label":13,"type":10,"description":14,"interventionNames":10},"B","1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography\n2. Bio-specimen collection\n3. Six-minute walk test\n4. Musculoskeletal Analysis",{"label":16,"type":10,"description":14,"interventionNames":10},"C",{"label":18,"type":10,"description":19,"interventionNames":10},"D","1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography\n2. Bio-specimen collection\n3. Six-minute walk test (may require separate day visit to complete)\n4. Musculoskeletal Analysis\n5. Questionnaires",[21],{"facility":5,"status":22,"city":23,"state":23,"zip":24,"country":23,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"RECRUITING","Singapore","169609","SG",{"type":27,"coordinates":28},"Point",[29,30],103.85007,1.28967,{"lat":30,"lon":29},[33,38],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"Angela Koh, M.D.","CONTACT","67042228","angela.koh.s.m@singhealth.com.sg",{"name":39,"role":40,"phone":10,"phoneExt":10,"email":10},"Angela Koh, M.D","PRINCIPAL_INVESTIGATOR",{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100498840",false,"NCT05775484","Exercise to Slow Cardiovascular Ageing Progression","Inclusion Criteria:\n\n* Age \\>=21 years old\n* Outdoor ambulant\n\nExclusion Criteria:\n\n* Wheelchair or bed-bound\n* Dementia\n* Residing in sheltered or nursing home\n* Cancer\n* Participation in ongoing clinical trials that involve interventional drugs or devices\n* Aneurysms\n* Acute infections (in the last six months)\n* Uncontrolled thyrotoxicosis\n* Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise\n* Uncontrolled asthma or chronic lung disease\n* Restrictive lung disease",true,"ALL","21 Years","100 Years",{"count":53,"type":54},450,"ESTIMATED","OBSERVATIONAL","In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.",[58,59,60],"Cardiac Ageing","Exercise","Cardiovascular","2025-06-03",{"date":63,"type":64},"2025-06-05","ACTUAL",{"date":66,"type":64},"2023-05-01",{"date":68,"type":54},"2050-12-31",{"name":5,"class":6},1]