Exercise Training and Fat Metabolism in Postmenopausal Women

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age50-75
SponsorFlorida State University

About this trial

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Eligibility criteria

Qualifiers

Women

Postmenopausal (50-75 yrs.)

Obese (BMI 30-50 kg/m2)

Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)

Disqualifiers

Engaging in purposeful resistance training or endurance training (> 20min/day, > 2 days/week)

Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic

Type 1 or type 2 diabetes

Medical problems in which exercise is contraindicated, such as chronic infections

Trial design

Treatments tested in this trial

  • Resistance Exercise
  • Endurance Exercise

Treatment groups

120 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Florida State University

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Pennington Biomedical Research Center

Collaborator

University of Arkansas

Collaborator