[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608781":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":32,"responsibleParty":51,"collaborators":18,"id":53,"slug":18,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":18,"enrollmentInfo":62,"targetDuration":18,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":18,"overallStatus":35,"whyStopped":18,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University Medical Center Groningen","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"prebiotic dried chicory root (WholeFiber)","EXPERIMENTAL","Supplementing with WholeFiber for 6 weeks two times a day (10 g per portion). During 3 visits questionnaires, measurements and (blood and fecal) samples will be taken.",[13],"Other: prebiotic dried chicory root (WholeFiber)",[15],{"type":6,"name":9,"description":16,"armGroupLabels":17,"otherNames":18},"Supplementing with WholeFiber for 6 weeks two times a day (10 g per portion).",[9],null,[20],{"name":21,"affiliation":5,"role":22},"G. A.P. Hospers, MD, PhD","PRINCIPAL_INVESTIGATOR",[24,28],{"name":21,"role":25,"phone":26,"phoneExt":18,"email":27},"CONTACT","+31 50 361 2821","g.a.p.hospers@umcg.nl",{"name":29,"role":25,"phone":30,"phoneExt":18,"email":31},"Emily Oosterhout, MSc","+31652764949","e.oosterhout@umcg.nl",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"UMCG","RECRUITING","Groningen","Provincie Groningen","9713 GZ","Netherlands","NL",{"type":42,"coordinates":43},"Point",[44,45],6.56667,53.21917,{"lat":45,"lon":44},[48,49,50],{"name":21,"role":25,"phone":26,"phoneExt":18,"email":27},{"name":29,"role":25,"phone":30,"phoneExt":18,"email":31},{"name":21,"role":22,"phone":18,"phoneExt":18,"email":18},{"type":52,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100608781",false,"NCT07206017","Explorative Study on Addition of High-fiber Dried Chicory Root in Patients With an Intermediate to High-risk Cutaneous Melanoma.","Measuring Effects of High-fiber Dried Chicory Root on the Gut Microbiota of Patients With an Intermediate to High-risk Cutaneous Melanoma: an Explorative Study","MELFIB","Inclusion Criteria:\n\n* Age ≥18 years;\n* The participant understands the study and can provide written informed consent;\n* The participant received surgical treatment of an intermediate to high-risk cutaneous melanoma (T2a\u002FN1, T2b, T3a, T3b, T4a, T4b, N0 or N+, M0 stadium without evidence of disease);\n* Being able to read and speak Dutch;\n* Willing to come to the UMCG for practical reasons (visiting the study site);\n* Willing to continue their regular lifestyle patterns during the study.\n\nExclusion Criteria:\n\n* Receiving concurrent adjuvant treatment, adjuvant treatment after the study period is allowed.\n* Having a medical history that may impact study outcomes, such as a diagnosis of diabetes mellitus type 2, heart disease, renal disease, autoimmune disease;\n* Any clinically significant or unstable medical disorder involving the gut, including celiac disease, inflammatory bowel disease, short-bowel syndrome or acute\u002Fchronic pancreatitis;\n* Having an ileostomy or colostomy, as this greatly impacts bowel function and gut microbial composition;\n* Use of antibiotics in the 3 months prior participation in the study;\n* Use of prednisolone or other immunosuppressive medication;\n* Use of tube feeding or sib-feeding;\n* Being pregnant or lactating;\n* Participation in another interventional study at the same time;\n* Unable or unwilling to comply to study rules.","ALL","18 Years",{"count":63,"type":64},20,"ESTIMATED","INTERVENTIONAL",[67],"NA","Exploring the effect of supplementation with daily addition of prebiotic dried chicory root (WholeFiberTM) for 6 weeks on fecal SCFA levels, gut microbial composition and immune cell composition in minimal stage II A melanoma patients following surgical treatment.",[70],"Melanoma, Stage II","2025-09-25",{"date":73,"type":74},"2025-10-03","ACTUAL",{"date":76,"type":74},"2025-03-26",{"date":78,"type":64},"2027-09-14",{"name":5,"class":6},1]