About this trial
The goal of this clinical trial is to learn whether consuming a high fermented food diet improves bowel function and gut health in adults with chronic spinal cord injury (SCI). The study will also evaluate the feasibility and tolerability of consuming fermented foods daily for 10 weeks. The main questions it aims to answer are:
1. Does a high fermented food diet improve neurogenic bowel dysfunction symptoms and colonic transit in adults with SCI? 2. Does fermented food intake change gut microbiome composition, short-chain fatty acid production, and intestinal inflammation?
Researchers will compare a high fermented food diet to a control diet to evaluate effects on bowel health and gut microbiome outcomes.
Participants will:
* Consume study foods daily for 10 weeks * Attend 2 in-person study visits * Collect stool samples at home and ship them overnight to the research team using provided collection kits and prepaid shipping materials * Complete bowel health questionnaires and dietary recalls * Undergo Sitz marker testing with abdominal X-rays to assess colonic transit * Participate in biweekly monitoring contacts throughout the study period
Eligibility criteria
Qualifiers
Adults aged 18-70 years
At least 1 year post-onset of spinal cord injury, consistent with chronic spinal cord injury
Traumatic spinal cord injury involving cervical or thoracic levels
American Spinal Injury Association Impairment Scale classification A-D
Disqualifiers
Antibiotic use within the past 4 weeks
Active gastrointestinal disease, including Crohn's disease, ulcerative colitis, celiac disease, or gastrointestinal obstruction
Current intake of probiotics or fermented foods exceeding 3 servings per day
Pregnancy or breastfeeding
Trial design
Treatments tested in this trial
- fermented foods
- Control diet
- Sitz Marker Test