[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577038":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":35,"centralContacts":39,"locations":48,"responsibleParty":60,"collaborators":10,"id":64,"slug":10,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Jagiellonian University","OTHER",[8,15,18],{"label":9,"type":10,"description":10,"interventionNames":11},"Women with polycystic ovary syndrome (PCOS) and insulin resistance (IR)",null,[12,13,14],"Diagnostic Test: Measurement of kisspeptin concentration","Diagnostic Test: Measurement of ghrelin concentration","Diagnostic Test: Measurement of zonulin concentration",{"label":16,"type":10,"description":10,"interventionNames":17},"Women with polycystic ovary syndrome (PCOS) without insulin resistance (IR)",[12,13,14],{"label":19,"type":10,"description":10,"interventionNames":20},"Women without PCOS",[12,13,14],[22,27,31],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Measurement of kisspeptin concentration","Measurement of kisspeptin concentration in fasting venous blood serum",[9,16,19],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Measurement of ghrelin concentration","Measurement of ghrelin concentration in fasting venous blood serum",[9,16,19],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Measurement of zonulin concentration","Measurement of zonulin concentration in fasting venous blood serum",[9,16,19],[36],{"name":37,"affiliation":5,"role":38},"Kazimierz Pityński, Prof., Ph.D., M.D.","STUDY_CHAIR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":10,"email":44},"Iwona Gawron, Ph.D., M.D.","CONTACT","+48 124248570","iwona.gawron@uj.edu.pl",{"name":46,"role":42,"phone":43,"phoneExt":10,"email":47},"Robert Jach, Prof., Ph.D., M.D.","jach@cm-uj.krakow.pl",[49],{"facility":5,"status":50,"city":51,"state":10,"zip":10,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":10},"RECRUITING","Krakow","Poland","PL",{"type":55,"coordinates":56},"Point",[57,58],19.93658,50.06143,{"lat":58,"lon":57},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Iwona Magdalena Gawron","PhD, MD, Principal Investigator","100577038",false,"NCT06793098","Functional Proteins in Polycystic Ovary Syndrome","Assessment of the Concentrations of Functional Proteins as Potential Early Markers of Insulin Resistance in Women With Polycystic Ovary Syndrome","Inclusion Criteria:\n\n* women aged 18-45 years\n\nExclusion Criteria:\n\n* removal of at least one ovary\n* treated diabetes of any type\n* diagnosed and treated metabolic diseases\n* diagnosed and treated autoimmune diseases\n* diagnosed and treated autoinflammatory diseases",true,"FEMALE","18 Years","45 Years",{"count":75,"type":76},100,"ESTIMATED","OBSERVATIONAL","The concentration of functional proteins: kisspeptin, ghrelin, zonulin will be measured and compared in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR), in women with PCOS without IR, and in women without PCOS.",[80,81],"Reproductive Age","PCOS (Polycystic Ovary Syndrome)",[83,84,85,86,87,88],"insulin resistance","kisspeptin","ghrelin","zonulin","metabolic syndrome","Polycystic Ovary Syndrome","2026-03-17",{"date":91,"type":92},"2026-03-18","ACTUAL",{"date":94,"type":92},"2025-01-20",{"date":96,"type":76},"2027-12-31",{"name":5,"class":6},1]