Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)
ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorLille University
About this trial
The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Male or female
Aged between 18 and 35
Weighing more than 50 kg
Member of a sports club affiliated to an Olympic federation
Disqualifiers
Medical history contraindicating sporting activities
Current medical treatment
Not a member of a sports club affiliated to an Olympic federation
Administrative reasons: impossibility of receiving informed information, impossibility of participating in the entire study, absence of social security coverage, refusal to sign consent form.
Trial design
Design model
Single group
Treatments tested in this trial
Exercise
Other interventionMuscle induced-damage eccentric exercise
Treatment groups
300 Participants
are divided into 1 treatment groupGroup A: ExerciseExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
The association between single nucleotide polymorphisms and exercise induced blood creatine kinase variation
Association between blood creatine kinase level variations and single nucleotide polymorphisms. The Outcome Measure in this study is focused on the variation in plasma CPK levels following an exercise inducing muscle damage. The result is expressed as a change in plasma CPK concentration, measured in units per liter (U/L). This single measurement is used to investigate its association with genetic polymorphisms. Therefore a regression analysis will be performed to identify the association. This study is exploratory and the genetic polymorphisms are not pre-identified but will be investigated through a comprehensive analysis.
Time frame
Evolution of kinetics from Day 0 to Day 3 post experimentSponsors and contacts
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Source ClinicalTrials.gov