[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053513":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":27,"studyPopulation":28,"armGroups":29,"interventions":23,"overallOfficials":33,"centralContacts":41,"locations":48,"responsibleParty":521,"collaborators":524,"id":532,"slug":23,"hasResults":533,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":537,"eligibilityCriteria":538,"healthyVolunteers":533,"sex":539,"minAge":23,"maxAge":23,"enrollmentInfo":540,"targetDuration":543,"studyType":544,"phases":23,"briefSummary":545,"conditions":546,"keywords":565,"overallStatus":51,"whyStopped":23,"lastUpdateSubmitDate":567,"lastUpdatePostDateStruct":568,"startDateStruct":571,"completionDateStruct":573,"leadSponsor":575,"locationsCount":576},{"fullName":5,"class":6},"LMU Klinikum","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":23,"otherOutcomes":23},[9,13,17,20],{"measure":10,"description":11,"timeFrame":12},"Newcastle Mitochondrial Disease Scale for Adults (NMDAS), Sections I-III","Newcastle Mitochondrial Disease Scale for Adults (NMDAS) is a clinical rating scale designed for mitochondrial disease. The rating scale explores several domains: current function, system specific involvement and current clinical assessment. The individual scores are summed to provide a total score that ranges from 0 to 145; higher scores indicate more severely affection.","The individual participants are followed with annual assessments over a long time period (up to 30 years) or until discontinuation or death.",{"measure":14,"description":15,"timeFrame":16},"Newcastle Pediatric Mitochondrial Disease Scale for Children (NPMDS)","NPMDS is a clinical rating scale designed for mitochondrial disease in children.\n\nThere are three versions of the NPMDS, each for a specific age range (0-24 months, 2-11 years, and 12-18 years). The rating scale explores several domains: current function (Section I), system specific involvement (Section II), current clinical assessment (Section III) and quality of life (QoL) assessments (Section IV). The individual scores in Section I-III are summed to provide a total score that ranges from 0 to 70 (version 0-24month) and 0-82 (versions 2-18 years); higher scores indicate more severely affection. Section IV (QoL) is scored separately and provide a total score that ranges from 0 to 25 with higher scores indicating better quality of life.","The individual participants are followed with annual assessments until they reach the next age group version (up to 18 years) or until discontinuation or death.",{"measure":18,"description":19,"timeFrame":12},"Scale for the assessment and rating of ataxia (SARA) in adults","The Scale for the Assessment and Rating of Ataxia (SARA) is a clinical scale used to assess cerebellar ataxia in adults. The scale includes 8 items, related to gait, stance, sitting, speech, finger-chase test, nose-finger test, fast alternating movements and heel-shin test. The individual scores are summed to provide a total score that ranges from 0 to 40, higher scores indicate more severe ataxia.",{"measure":21,"description":22,"timeFrame":12},"Disease progression","Disease progression as assessed by clinical examination and captured as HPO (Human Phenotype Ontology) Terms at each visit.",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":25,"timePerspective":26,"maskingInfo":23},"COHORT","PROSPECTIVE","The global mitochondrial registry and natural history study is part of the EU-financed GENOMIT project, co-ordinated by Dr. Holger Prokisch, Technische Universität München (TUM).It aims at advancing the understanding of the natural history of mitochondrial disease to inform the design and facilitate the conduction of clinical trials. It also serves as a catalyst for translating basic research results into clinical practice.\n\nThe global mitochondrial registry and natural history study provides for all contingencies of national ethics and data protection rules including data access management.\n\nCurrently participating networks are:\n\n* German network for mitochondrial diseases - mitoNET, Germany\u002FAustria\n* Italian Registry of Mitochondrial Patients - Mitocon, Italy\n\nThe inclusion of other networks and countries is possible and explicitly welcome. A major advantage of the global registry is that countries can join in, saving a lot of time, effort and funding.","All",[30],{"label":31,"type":23,"description":32,"interventionNames":23},"Mitochondrial patients","Patients with a suspected or confirmed mitochondrial disease.",[34,38],{"name":35,"affiliation":36,"role":37},"Thomas Klopstock, Prof. Dr.","LMU Klinikum, Munich","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":40,"role":37},"Michelangelo Mancuso, Prof. Dr.","Università di Pisa",[42],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Boriana Büchner, Dr.","CONTACT","+49 89 4400","57067","boriana.buechner@med.uni-muenchen.de",[49,68,85,104,118,131,145,159,174,193,208,222,233,242,259,274,291,305,321,333,343,357,371,385,399,413,427,438,453,464,482,493,507],{"facility":50,"status":51,"city":52,"state":23,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Medical University Innsbruck, Department of Pediatrics","RECRUITING","Innsbruck","6020","Austria","AT",{"type":57,"coordinates":58},"Point",[59,60],11.39454,47.26266,{"lat":60,"lon":59},[63],{"name":64,"role":44,"phone":65,"phoneExt":66,"email":67},"Daniela Karall, Prof. Dr.","+43 512 504","23600","daniela.karall@i-med.ac.at",{"facility":69,"status":51,"city":70,"state":23,"zip":71,"country":54,"countryCode":55,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Salzburger Landeskliniken, SALK, Paracelsus Medizinische Privatuniversität","Salzburg","5020",{"type":57,"coordinates":73},[74,75],13.04399,47.79941,{"lat":75,"lon":74},[78,82],{"name":79,"role":44,"phone":80,"phoneExt":81,"email":23},"Saskia Wortmann, PD Dr. med.","+43 5 7255","26222",{"name":83,"role":44,"phone":80,"phoneExt":81,"email":84},"Elisa Floride, Dr.","e.floride@salk.at",{"facility":86,"status":51,"city":87,"state":88,"zip":89,"country":90,"countryCode":91,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Department of neurology, Klinikum rechts der Isar, Technical University Munich","Munich","Bavaria","81675","Germany","DE",{"type":57,"coordinates":93},[94,95],11.57549,48.13743,{"lat":95,"lon":94},[98,102],{"name":99,"role":44,"phone":100,"phoneExt":101,"email":23},"Marcus Deschauer, Prof. Dr.","+49 89 4140","4617",{"name":103,"role":44,"phone":23,"phoneExt":23,"email":23},"Luisa Semmler",{"facility":105,"status":51,"city":106,"state":23,"zip":107,"country":90,"countryCode":91,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Charité Virchow Klinikum, Klinik für Pädiatrie m. S. Neurologie","Berlin","13353",{"type":57,"coordinates":109},[110,111],13.41053,52.52437,{"lat":111,"lon":110},[114],{"name":115,"role":44,"phone":116,"phoneExt":23,"email":117},"Markus Schülke-Gerstenfeld, Prof.Dr.med.","+49 30 4505 66112","Markus.Schuelke@charite.de",{"facility":119,"status":51,"city":120,"state":23,"zip":23,"country":90,"countryCode":91,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Universität Bonn, Klinik und Poliklinik für Neurologie","Bonn",{"type":57,"coordinates":122},[123,124],7.09549,50.73438,{"lat":124,"lon":123},[127],{"name":128,"role":44,"phone":129,"phoneExt":23,"email":130},"Cornelia Kornblum, Prof. Dr.","+49 228 287 15712","Cornelia.Kornblum@ukbonn.de",{"facility":132,"status":51,"city":133,"state":23,"zip":134,"country":90,"countryCode":91,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"Universitätsklinikum Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin","Cologne","50931",{"type":57,"coordinates":136},[137,138],6.95,50.93333,{"lat":138,"lon":137},[141],{"name":142,"role":44,"phone":143,"phoneExt":23,"email":144},"Jürgen-Christoph von Kleist-Retzow, PD Dr.","+49 221 478 5900","juergen-christoph.vonkleist@uk-koeln.de",{"facility":146,"status":51,"city":147,"state":23,"zip":148,"country":90,"countryCode":91,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"Universitätsklinikum Düsseldorf, Klinik für allgemeine Pädiatrie, Neonatologie und Kinderkardiologie","Düsseldorf","40225",{"type":57,"coordinates":150},[151,152],6.77927,51.22319,{"lat":152,"lon":151},[155],{"name":156,"role":44,"phone":157,"phoneExt":23,"email":158},"Felix Distelmaier, Prof. Dr.","+49 211 811 7696","Felix.Distelmaier@med.uni-duesseldorf.de",{"facility":160,"status":51,"city":161,"state":23,"zip":162,"country":90,"countryCode":91,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"Universitätsklinikum Frankfurt, Klinik für Kinder- und Jugendmedizin, Schwerpunkt Neurologie, Neurometabolik und Prävention","Frankfurt am Main","60590",{"type":57,"coordinates":164},[165,166],8.68417,50.11552,{"lat":166,"lon":165},[169,172],{"name":170,"role":44,"phone":171,"phoneExt":23,"email":23},"Matthias Kieslich, Prof.Dr.med.","+49 69 6301 5560",{"name":173,"role":44,"phone":23,"phoneExt":23,"email":23},"Martin Lindner, PD Dr. med.",{"facility":175,"status":51,"city":176,"state":23,"zip":177,"country":90,"countryCode":91,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"University Medical Center Freiburg, Center for children and youth medicine","Freiburg im Breisgau","79106",{"type":57,"coordinates":179},[180,181],7.85222,47.9959,{"lat":181,"lon":180},[184,189],{"name":185,"role":44,"phone":186,"phoneExt":187,"email":188},"Matthias Eckenweiler, Dr.","+49 761 270","43750","matthias.eckenweiler@uniklinik-freiburg.de",{"name":190,"role":44,"phone":186,"phoneExt":191,"email":192},"Simone Bürklin","44970","simone.buerklin@uniklinik-freiburg.de",{"facility":194,"status":51,"city":195,"state":23,"zip":196,"country":90,"countryCode":91,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Martin-Luther-Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik","Halle","06097",{"type":57,"coordinates":198},[199,200],11.97947,51.48158,{"lat":200,"lon":199},[203,206],{"name":204,"role":44,"phone":205,"phoneExt":23,"email":23},"Alexander Mensch, Dr. med.","49 345 557 2856",{"name":207,"role":44,"phone":23,"phoneExt":23,"email":23},"Annamarie Thäle, Dr. med.",{"facility":209,"status":51,"city":210,"state":23,"zip":211,"country":90,"countryCode":91,"cosmosGeoPoint":212,"geoPoint":216,"contacts":217},"Universitätsklinikum Hamburg Eppendorf Institut für Humangenetik","Hamburg","20246",{"type":57,"coordinates":213},[214,215],9.99302,53.55073,{"lat":215,"lon":214},[218],{"name":219,"role":44,"phone":220,"phoneExt":23,"email":221},"Maja Hempel, PD Dr. med.","+49 40 7410 50772","m.hempel@uke.de",{"facility":223,"status":51,"city":210,"state":23,"zip":211,"country":90,"countryCode":91,"cosmosGeoPoint":224,"geoPoint":226,"contacts":227},"Universitätsklinikum Hamburg Eppendorf, Klinik für Kinder-und Jugendmedizin",{"type":57,"coordinates":225},[214,215],{"lat":215,"lon":214},[228,231],{"name":229,"role":44,"phone":230,"phoneExt":23,"email":23},"René Santer, Prof.Dr.med.","+49 40 7410 52710",{"name":232,"role":44,"phone":23,"phoneExt":23,"email":23},"Konstantinos Tsiakas, Dr. med.",{"facility":234,"status":51,"city":210,"state":23,"zip":211,"country":90,"countryCode":91,"cosmosGeoPoint":235,"geoPoint":237,"contacts":238},"Universitätsklinikum Hamburg Eppendorf, Klinik für Neurologie",{"type":57,"coordinates":236},[214,215],{"lat":215,"lon":214},[239],{"name":240,"role":44,"phone":23,"phoneExt":23,"email":241},"Simone Zittel-Dirks, PD Dr. med.","s.zittel-dirks@uke.de",{"facility":243,"status":51,"city":244,"state":23,"zip":245,"country":90,"countryCode":91,"cosmosGeoPoint":246,"geoPoint":250,"contacts":251},"Universitätsklinikum Heidelberg, Zentrum für Kinder- und Jugendmedizin, Sektion für Neuropädiatrie und Stoffwechselmedizin","Heidelberg","69120",{"type":57,"coordinates":247},[248,249],8.69079,49.40768,{"lat":249,"lon":248},[252,255],{"name":253,"role":44,"phone":254,"phoneExt":23,"email":23},"Georg F. Hoffmann, Prof. Dr.","+49 6221 56 4837",{"name":256,"role":44,"phone":257,"phoneExt":23,"email":258},"Nikolas Boy, PD Dr. med.","+49 6221 56 4002","nikolas.boy@med.uni-heidelberg.de",{"facility":260,"status":51,"city":261,"state":23,"zip":262,"country":90,"countryCode":91,"cosmosGeoPoint":263,"geoPoint":267,"contacts":268},"LMU Klinikum, Friedrich-Baur-Institut an der Neurologischen Klinik und Poliklinik","München","80336",{"type":57,"coordinates":264},[265,266],13.31243,51.60698,{"lat":266,"lon":265},[269,271],{"name":35,"role":44,"phone":270,"phoneExt":23,"email":23},"+49 89 4400 57400",{"name":272,"role":44,"phone":273,"phoneExt":23,"email":47},"Boriana Büchner, Dr. med.","+49 89 4400 57067",{"facility":275,"status":51,"city":276,"state":23,"zip":277,"country":90,"countryCode":91,"cosmosGeoPoint":278,"geoPoint":282,"contacts":283},"Klinikum am Steinenberg, Kreiskliniken Reutlingen, Klinik für Kinder-und Jugendmedizin, Perinatal- u. Stoffwechselzentrum","Reutlingen","72764",{"type":57,"coordinates":279},[280,281],9.20427,48.49144,{"lat":281,"lon":280},[284,288],{"name":285,"role":44,"phone":286,"phoneExt":23,"email":287},"Peter Freisinger, Prof. Dr.","+49 7121 200 4051","freisinger_p@klin-rt.de",{"name":289,"role":44,"phone":290,"phoneExt":23,"email":23},"Vanessa Kock, Dr. med.","+49 7121 200 4060",{"facility":292,"status":51,"city":293,"state":23,"zip":294,"country":90,"countryCode":91,"cosmosGeoPoint":295,"geoPoint":299,"contacts":300},"Universitätsklinikum Tübingen, Neurologische Klinik und Hertie Institut für Klinische Hirnforschung","Tübingen","72076",{"type":57,"coordinates":296},[297,298],9.05222,48.52266,{"lat":298,"lon":297},[301],{"name":302,"role":44,"phone":303,"phoneExt":23,"email":304},"Ludger Schöls, Prof. Dr.","+49 7071 29 82057","ludger.schoels@uni-tuebingen.de",{"facility":306,"status":51,"city":307,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":310,"geoPoint":314,"contacts":315},"Sant'Orsola-Malpighi University Hospital","Bologna","Italy","IT",{"type":57,"coordinates":311},[312,313],11.33875,44.49381,{"lat":313,"lon":312},[316,319],{"name":317,"role":44,"phone":23,"phoneExt":23,"email":318},"Rita Rinaldi, Prof. dr.","rita.rinaldi@aosp.bo.it",{"name":320,"role":37,"phone":23,"phoneExt":23,"email":23},"Rita Rinaldi",{"facility":322,"status":51,"city":307,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":323,"geoPoint":325,"contacts":326},"University of Bologna",{"type":57,"coordinates":324},[312,313],{"lat":313,"lon":312},[327,329,330],{"name":328,"role":44,"phone":23,"phoneExt":23,"email":23},"Valerio Carelli, Prof. dr.",{"name":328,"role":37,"phone":23,"phoneExt":23,"email":23},{"name":331,"role":332,"phone":23,"phoneExt":23,"email":23},"Chiara La Morgia","SUB_INVESTIGATOR",{"facility":322,"status":51,"city":307,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":334,"geoPoint":336,"contacts":337},{"type":57,"coordinates":335},[312,313],{"lat":313,"lon":312},[338,341],{"name":339,"role":44,"phone":23,"phoneExt":23,"email":340},"Caterina Garone, Prof. dr.","caterina.garone@unibo.it",{"name":342,"role":37,"phone":23,"phoneExt":23,"email":23},"Caterina Garone",{"facility":344,"status":51,"city":345,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":346,"geoPoint":350,"contacts":351},"Nemo Clinical Center","Brescia",{"type":57,"coordinates":347},[348,349],10.21472,45.53558,{"lat":349,"lon":348},[352,355],{"name":353,"role":44,"phone":23,"phoneExt":23,"email":354},"Massimiliano Filosto, Prof. dr.","massimiliano.filosto@unibs.it",{"name":356,"role":37,"phone":23,"phoneExt":23,"email":23},"Massimiliano Filosto",{"facility":358,"status":51,"city":359,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":360,"geoPoint":364,"contacts":365},"University of Cagliari","Cagliari",{"type":57,"coordinates":361},[362,363],9.11917,39.23054,{"lat":363,"lon":362},[366,369],{"name":367,"role":44,"phone":23,"phoneExt":23,"email":368},"Maria Antonietta Maioli, dr. med","ma.maioli@tiscali.it",{"name":370,"role":37,"phone":23,"phoneExt":23,"email":23},"Maria Antonietta Maioli",{"facility":372,"status":51,"city":373,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":374,"geoPoint":378,"contacts":379},"AOU Meyer IRCCS Children's Hospital","Florence",{"type":57,"coordinates":375},[376,377],11.24626,43.77925,{"lat":377,"lon":376},[380,383],{"name":381,"role":44,"phone":23,"phoneExt":23,"email":382},"Elena Procopio, dr. med","e.procopio@meyer.it",{"name":384,"role":37,"phone":23,"phoneExt":23,"email":23},"Elena Procopio",{"facility":386,"status":51,"city":387,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":388,"geoPoint":392,"contacts":393},"Giannina Gaslini Children's Hospital","Genova",{"type":57,"coordinates":389},[390,391],11.87211,45.21604,{"lat":391,"lon":390},[394,397],{"name":395,"role":44,"phone":23,"phoneExt":23,"email":396},"Claudio Bruno, Prof. dr.","claudiobruno@gaslini.org",{"name":398,"role":37,"phone":23,"phoneExt":23,"email":23},"Claudio Bruno, Bruno",{"facility":400,"status":51,"city":401,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":402,"geoPoint":406,"contacts":407},"University Hospital G. Martino","Messina",{"type":57,"coordinates":403},[404,405],15.55256,38.19394,{"lat":405,"lon":404},[408,411],{"name":409,"role":44,"phone":23,"phoneExt":23,"email":410},"Olimpia Musumeci, Prof. dr.","omusumeci@unime.it",{"name":412,"role":37,"phone":23,"phoneExt":23,"email":23},"Olimpia Musumeci",{"facility":414,"status":51,"city":415,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":416,"geoPoint":420,"contacts":421},"IRCCS Foundation Ca' Granda - Ospedale Maggiore","Milan",{"type":57,"coordinates":417},[418,419],9.18951,45.46427,{"lat":419,"lon":418},[422,425],{"name":423,"role":44,"phone":23,"phoneExt":23,"email":424},"Giacomo Pietro Comi, Prof. dr.","giacomo.comi@unimi.it",{"name":426,"role":37,"phone":23,"phoneExt":23,"email":23},"Giacomo Pietro Comi",{"facility":428,"status":51,"city":415,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":429,"geoPoint":431,"contacts":432},"IRCCS Foundation Carlo Besta Neurological Institute",{"type":57,"coordinates":430},[418,419],{"lat":419,"lon":418},[433,436],{"name":434,"role":44,"phone":23,"phoneExt":23,"email":435},"Costanza Lamperti, dr. med","costanza.lamperti@istituto-besta.it",{"name":437,"role":37,"phone":23,"phoneExt":23,"email":23},"Costanza Lamperti",{"facility":439,"status":51,"city":440,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":441,"geoPoint":445,"contacts":446},"Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa & AOUP","Pisa",{"type":57,"coordinates":442},[443,444],10.4036,43.70853,{"lat":444,"lon":443},[447,451],{"name":448,"role":44,"phone":449,"phoneExt":23,"email":450},"Michaelangelo Mancuso, Prof. Dr.","+39 (0)50 992443","michelangelo.mancuso@unipi.it",{"name":452,"role":37,"phone":23,"phoneExt":23,"email":23},"Michelangelo Mancuso",{"facility":454,"status":51,"city":440,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":455,"geoPoint":457,"contacts":458},"IRCCS Foundation Stella Maris",{"type":57,"coordinates":456},[443,444],{"lat":444,"lon":443},[459,462],{"name":460,"role":44,"phone":23,"phoneExt":23,"email":461},"Filippo Santorelli, dr. med","filippo3364@gmail.com",{"name":463,"role":37,"phone":23,"phoneExt":23,"email":23},"Filippo Santorelli",{"facility":465,"status":51,"city":466,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":467,"geoPoint":471,"contacts":472},"Bambino Gesù Children's Hospital","Rome",{"type":57,"coordinates":468},[469,470],12.51133,41.89193,{"lat":470,"lon":469},[473,476,478,480],{"name":474,"role":44,"phone":23,"phoneExt":23,"email":475},"Enrico Silvio Bertini, Prof. dr.","enricosilvio.bertini@opbg.net",{"name":477,"role":37,"phone":23,"phoneExt":23,"email":23},"Enrico Silvio Bertini",{"name":479,"role":332,"phone":23,"phoneExt":23,"email":23},"Diego Martinelli",{"name":481,"role":332,"phone":23,"phoneExt":23,"email":23},"Daria Diodato",{"facility":483,"status":51,"city":466,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":484,"geoPoint":486,"contacts":487},"University of Rome",{"type":57,"coordinates":485},[469,470],{"lat":470,"lon":469},[488,490,491],{"name":489,"role":44,"phone":23,"phoneExt":23,"email":23},"Serenella Servidei, Prof. dr.",{"name":489,"role":37,"phone":23,"phoneExt":23,"email":23},{"name":492,"role":332,"phone":23,"phoneExt":23,"email":23},"Guido Primiano, Prof. dr.",{"facility":494,"status":51,"city":495,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":496,"geoPoint":500,"contacts":501},"AOU City of Health and Science of Turin - Molinette Hospital","Turin",{"type":57,"coordinates":497},[498,499],7.68682,45.07049,{"lat":499,"lon":498},[502,505],{"name":503,"role":44,"phone":23,"phoneExt":23,"email":504},"Tiziana Prof, Dr. Mongini","tmongini@cittadellasalute.to.it",{"name":506,"role":37,"phone":23,"phoneExt":23,"email":23},"Tiziana Mongini",{"facility":508,"status":51,"city":509,"state":23,"zip":23,"country":308,"countryCode":309,"cosmosGeoPoint":510,"geoPoint":514,"contacts":515},"AOUI Verona","Verona",{"type":57,"coordinates":511},[512,513],10.9938,45.43854,{"lat":513,"lon":512},[516,519],{"name":517,"role":44,"phone":23,"phoneExt":23,"email":518},"Paola Tonin, Prof. dr.","paola.tonin@aovr.veneto.it",{"name":520,"role":37,"phone":23,"phoneExt":23,"email":23},"Paola Tonin",{"type":37,"investigatorFullName":522,"investigatorTitle":523,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Prof. Thomas Klopstock","Prof. Dr. Thomas Klopstock",[525,527,530],{"name":526,"class":6},"European Commission",{"name":528,"class":529},"German Federal Ministry of Education and Research","OTHER_GOV",{"name":531,"class":6},"University of Pisa","100053513",false,"NCT05554835","Global Registry and Natural History Study for Mitochondrial Disorders","Global Mitochondrial Registry to Define Natural History and Outcome Measures to Achieve Definite Trial Readiness for Mitochondrial Disorders","GENOMIT","Inclusion Criteria:\n\n* suspected or confirmed mitochondrial disease\n* willingness to participate\n\nExclusion Criteria:\n\n* unwillingness to participate","ALL",{"count":541,"type":542},6000,"ESTIMATED","30 Years","OBSERVATIONAL","The main goal of the project is provision of a global registry for mitochondrial disorders to harmonize previous national registries, enable world-wide participation and facilitate natural history studies, definition of outcome measures and conduction of clinical trials.",[547,548,549,550,551,552,553,554,555,556,557,558,559,560,561,562,563,564],"Mitochondrial Diseases","Kearns-Sayre Syndrome","MIDD","SANDO","SCAE","NARP Syndrome","MELAS Syndrome","MERRF Syndrome","Coenzyme Q10 Deficiency","LHON","MNGIE","MIRAS","Barth Syndrome","MDS","Mitochondrial Myopathies","Leigh Syndrome","Pearson Syndrome","CPEO",[566],"Patient Registry","2026-07-09",{"date":569,"type":570},"2026-07-13","ACTUAL",{"date":572,"type":570},"2009-02-01",{"date":574,"type":542},"2040-12",{"name":5,"class":6},33]