[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538236":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":38,"centralContacts":42,"locations":51,"responsibleParty":75,"collaborators":77,"id":85,"slug":31,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":31,"eligibilityCriteria":90,"healthyVolunteers":86,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":31,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":54,"whyStopped":31,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Universidade Federal Fluminense","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Propolis associated with Royal Jelly Group","EXPERIMENTAL","4 capsules a day, providing daily royal jelly in an amount of 100 mg\u002Fday plus 500 mg\u002Fday of propolis together, for 2 months.",[13],"Dietary Supplement: Propolis associated with Royal Jelly",{"label":15,"type":10,"description":16,"interventionNames":17},"Royal Jelly","Royal Jelly will receive 1 capsule a day, providing daily royal jelly in an amount of 100 mg\u002Fday, for 2 months.",[18],"Dietary Supplement: Royal Jelly",{"label":20,"type":21,"description":22,"interventionNames":23},"Placebo","PLACEBO_COMPARATOR","4 capsules a day of placebo.",[24],"Dietary Supplement: Placebo",[26,32,35],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DIETARY_SUPPLEMENT","Propolis associated with Royal Jelly","The participants will consume 4 capsules a day, providing daily royal jelly in an amount of 100 mg\u002Fday plus 500 mg\u002Fday of propolis together, for 2 months.",[9],null,{"type":27,"name":15,"description":33,"armGroupLabels":34,"otherNames":31},"The participants will consume 1 capsules a day, providing daily royal jelly in an amount of 100 mg\u002Fday, for 2 months.",[15],{"type":27,"name":20,"description":36,"armGroupLabels":37,"otherNames":31},"The participant will consume 4 capsules a day of placebo, for 2 months.",[20],[39],{"name":40,"affiliation":5,"role":41},"Denise Mafra, PhD","PRINCIPAL_INVESTIGATOR",[43,47],{"name":40,"role":44,"phone":45,"phoneExt":31,"email":46},"CONTACT","5521985683003","dmafra30@gmail.com",{"name":48,"role":44,"phone":49,"phoneExt":31,"email":50},"Ludmila Cardozo, PhD","5521987333185","ludmila.cardozo@gmail.com",[52,69],{"facility":53,"status":54,"city":55,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Denise Mafra","RECRUITING","Rio de Janeiro","22260050","Brazil","BR",{"type":60,"coordinates":61},"Point",[62,63],-43.18223,-22.90642,{"lat":63,"lon":62},[66],{"name":67,"role":44,"phone":68,"phoneExt":31,"email":46},"Denise Mafra, phd","21985683003",{"facility":53,"status":54,"city":55,"state":55,"zip":31,"country":57,"countryCode":58,"cosmosGeoPoint":70,"geoPoint":72,"contacts":73},{"type":60,"coordinates":71},[62,63],{"lat":63,"lon":62},[74],{"name":53,"role":44,"phone":45,"phoneExt":31,"email":46},{"type":76,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR",[78,81,83],{"name":79,"class":80},"Conselho Nacional de Desenvolvimento Científico e Tecnológico","OTHER_GOV",{"name":82,"class":80},"Rio de Janeiro State Research Supporting Foundation (FAPERJ)",{"name":84,"class":80},"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.","100538236",false,"NCT06288204","Green Propolis Extract and Royal Jelly in Hypertensive Patients and\u002For With Chronic Kidney Disease","Association of Green Propolis Extract and Royal Jelly to Modulate Inflammation and Oxidative Stress in Hypertensive Patients and\u002For With Chronic Kidney Disease","Inclusion Criteria:\n\n* patients in stages 3 and 5 of CKD (GFR from 15 to 59 mL\u002Fmin),\n* patients receiving ambulatorial nutrition treatment at least 6 months\n* patients on regular Hemodialysis treatment for at least 6 months\n* patients using one to three antihypertensive drugs\n\nExclusion Criteria:\n\n* autoimmune and infectious diseases,\n* diabetes\n* cancer\n* AIDS\n* pregnant women\n* patients using catabolic drugs or antibiotics;\n* patients with catheter access to hemodialysis;\n* patients using antioxidant vitamin supplements, prebiotics, probiotics, symbiotic,\n* Patients on regular intake of propolis who are allergic to corn starch or report being allergic to bee stings.\n* patients with acute myocardial infarction (AMI) and\u002For cerebrovascular accident (CVA)","ALL","18 Years","75 Years",{"count":95,"type":96},153,"ESTIMATED","INTERVENTIONAL",[99],"NA","This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension (SAH), in a longitudinal, randomized, double-blind, placebo-controlled clinical trial that will be carried out for 2 months.",[102,103,104],"Chronic Kidney Diseases","Hypertension","Cardiovascular Diseases",[106,107,108,109,110,111,112,113,114],"chronic kidney disease","hypertension","cardiovascular disease","inflammation","oxidative stress","green propolis","royal jelly","Nrf2","Nuclear factor kappa-B","2026-05-14",{"date":117,"type":118},"2026-05-15","ACTUAL",{"date":120,"type":118},"2024-10-01",{"date":122,"type":96},"2027-07-31",{"name":5,"class":6},2]